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A possible role for kinase-associated protein phosphatase in the Arabidopsis CLAVATA1 signaling pathway
Continuous growth and development in plants are accomplished by meristems, groups of undifferentiated cells that persist as stem cells and initiate organs. While the structures of the apical and floral meristems in dicotyledonous plants have been well described, little is known about the underlying...
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| Published in: | Proceedings of the National Academy of Sciences - PNAS 1997-09, Vol.94 (19), p.10467-10472 |
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| container_end_page | 10472 |
| container_issue | 19 |
| container_start_page | 10467 |
| container_title | Proceedings of the National Academy of Sciences - PNAS |
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| creator | Williams, R.W Wilson, J.M Meyerowitz, E.M |
| description | Continuous growth and development in plants are accomplished by meristems, groups of undifferentiated cells that persist as stem cells and initiate organs. While the structures of the apical and floral meristems in dicotyledonous plants have been well described, little is known about the underlying molecular mechanisms controlling cell proliferation and differentiation in these structures. We have shown previously that the CLAVATA1 (CLV1) gene in Arabidopsis encodes a receptor kinase-like protein that controls the size of the apical and floral meristems. Here, we show that KAPP, a gene encoding a kinase-associated protein phosphatase, is expressed in apical and young floral meristems, along with CLV1. Overexpression of KAPP mimics the clv1 mutant phenotype. Furthermore, CLV1 has kinase activity: it phosphorylates both itself and KAPP. Finally, KAPP binds and dephosphorylates CLV1. We present a model where KAPP functions as a negative regulator of the CLAVATA1 signal transduction pathway |
| doi_str_mv | 10.1073/pnas.94.19.10467 |
| format | article |
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While the structures of the apical and floral meristems in dicotyledonous plants have been well described, little is known about the underlying molecular mechanisms controlling cell proliferation and differentiation in these structures. We have shown previously that the CLAVATA1 (CLV1) gene in Arabidopsis encodes a receptor kinase-like protein that controls the size of the apical and floral meristems. Here, we show that KAPP, a gene encoding a kinase-associated protein phosphatase, is expressed in apical and young floral meristems, along with CLV1. Overexpression of KAPP mimics the clv1 mutant phenotype. Furthermore, CLV1 has kinase activity: it phosphorylates both itself and KAPP. Finally, KAPP binds and dephosphorylates CLV1. We present a model where KAPP functions as a negative regulator of the CLAVATA1 signal transduction pathway</description><identifier>ISSN: 0027-8424</identifier><identifier>EISSN: 1091-6490</identifier><identifier>DOI: 10.1073/pnas.94.19.10467</identifier><identifier>PMID: 9294234</identifier><language>eng</language><publisher>United States: National Academy of Sciences of the United States of America</publisher><subject>ACTIVIDAD ENZIMATICA ; ACTIVITE ENZYMATIQUE ; Alleles ; Amino acids ; APICAL MERISTEMS ; Arabidopsis ; Arabidopsis - enzymology ; Arabidopsis Proteins ; ARABIDOPSIS THALIANA ; ARN MENSAJERO ; ARN MESSAGER ; AUTOPHOSPHORYLATION ; Biological Sciences ; Botany ; Carpels ; Enzymes ; ENZYMIC ACTIVITY ; ESTERASAS ; ESTERASE ; ESTERASES ; EXPRESION GENICA ; EXPRESSION DES GENES ; FLEUR ; FLORES ; FLOWERS ; FOSFORILACION ; GENE ; GENE EXPRESSION ; Gene Expression Regulation, Plant ; GENES ; INFLORESCENCE MERISTEMS ; KAPP GENE ; MERISTEMAS ; MERISTEMAS APICALES ; MERISTEME ; MERISTEME APICAL ; MERISTEMS ; MESSENGER RNA ; Phenotypes ; Phosphatases ; PHOSPHOPROTEIN PHOSPHATASE ; Phosphoprotein Phosphatases - genetics ; Phosphoprotein Phosphatases - metabolism ; PHOSPHORYLATION ; PLANTAS TRANSGENICAS ; PLANTE TRANSGENIQUE ; Plants ; Plants, Genetically Modified ; Protein Binding ; PROTEIN KINASE ; PROTEINA QUINASA ; PROTEINE KINASE ; Regulator genes ; RNA ; RNA, Messenger - genetics ; Signal Transduction ; STRUCTURAL GENES ; TRANSGENIC PLANTS</subject><ispartof>Proceedings of the National Academy of Sciences - PNAS, 1997-09, Vol.94 (19), p.10467-10472</ispartof><rights>Copyright 1993-1997 National Academy of Sciences</rights><rights>Copyright National Academy of Sciences Sep 16, 1997</rights><rights>Copyright © 1997, The National Academy of Sciences of the USA 1997</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c545t-81c512f2ab82d09a4f4d34b8922799f645fb6c188c2d25fd75a0e92c5e06c6643</citedby><cites>FETCH-LOGICAL-c545t-81c512f2ab82d09a4f4d34b8922799f645fb6c188c2d25fd75a0e92c5e06c6643</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Uhttp://www.pnas.org/content/94/19.cover.gif</thumbnail><linktopdf>$$Uhttps://www.jstor.org/stable/pdf/43230$$EPDF$$P50$$Gjstor$$H</linktopdf><linktohtml>$$Uhttps://www.jstor.org/stable/43230$$EHTML$$P50$$Gjstor$$H</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793,58238,58471</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9294234$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Williams, R.W</creatorcontrib><creatorcontrib>Wilson, J.M</creatorcontrib><creatorcontrib>Meyerowitz, E.M</creatorcontrib><title>A possible role for kinase-associated protein phosphatase in the Arabidopsis CLAVATA1 signaling pathway</title><title>Proceedings of the National Academy of Sciences - PNAS</title><addtitle>Proc Natl Acad Sci U S A</addtitle><description>Continuous growth and development in plants are accomplished by meristems, groups of undifferentiated cells that persist as stem cells and initiate organs. While the structures of the apical and floral meristems in dicotyledonous plants have been well described, little is known about the underlying molecular mechanisms controlling cell proliferation and differentiation in these structures. We have shown previously that the CLAVATA1 (CLV1) gene in Arabidopsis encodes a receptor kinase-like protein that controls the size of the apical and floral meristems. Here, we show that KAPP, a gene encoding a kinase-associated protein phosphatase, is expressed in apical and young floral meristems, along with CLV1. Overexpression of KAPP mimics the clv1 mutant phenotype. Furthermore, CLV1 has kinase activity: it phosphorylates both itself and KAPP. Finally, KAPP binds and dephosphorylates CLV1. We present a model where KAPP functions as a negative regulator of the CLAVATA1 signal transduction pathway</description><subject>ACTIVIDAD ENZIMATICA</subject><subject>ACTIVITE ENZYMATIQUE</subject><subject>Alleles</subject><subject>Amino acids</subject><subject>APICAL MERISTEMS</subject><subject>Arabidopsis</subject><subject>Arabidopsis - enzymology</subject><subject>Arabidopsis Proteins</subject><subject>ARABIDOPSIS THALIANA</subject><subject>ARN MENSAJERO</subject><subject>ARN MESSAGER</subject><subject>AUTOPHOSPHORYLATION</subject><subject>Biological Sciences</subject><subject>Botany</subject><subject>Carpels</subject><subject>Enzymes</subject><subject>ENZYMIC ACTIVITY</subject><subject>ESTERASAS</subject><subject>ESTERASE</subject><subject>ESTERASES</subject><subject>EXPRESION GENICA</subject><subject>EXPRESSION DES GENES</subject><subject>FLEUR</subject><subject>FLORES</subject><subject>FLOWERS</subject><subject>FOSFORILACION</subject><subject>GENE</subject><subject>GENE EXPRESSION</subject><subject>Gene Expression Regulation, Plant</subject><subject>GENES</subject><subject>INFLORESCENCE MERISTEMS</subject><subject>KAPP GENE</subject><subject>MERISTEMAS</subject><subject>MERISTEMAS APICALES</subject><subject>MERISTEME</subject><subject>MERISTEME APICAL</subject><subject>MERISTEMS</subject><subject>MESSENGER RNA</subject><subject>Phenotypes</subject><subject>Phosphatases</subject><subject>PHOSPHOPROTEIN PHOSPHATASE</subject><subject>Phosphoprotein Phosphatases - genetics</subject><subject>Phosphoprotein Phosphatases - metabolism</subject><subject>PHOSPHORYLATION</subject><subject>PLANTAS TRANSGENICAS</subject><subject>PLANTE TRANSGENIQUE</subject><subject>Plants</subject><subject>Plants, Genetically Modified</subject><subject>Protein Binding</subject><subject>PROTEIN KINASE</subject><subject>PROTEINA QUINASA</subject><subject>PROTEINE KINASE</subject><subject>Regulator genes</subject><subject>RNA</subject><subject>RNA, Messenger - genetics</subject><subject>Signal Transduction</subject><subject>STRUCTURAL GENES</subject><subject>TRANSGENIC PLANTS</subject><issn>0027-8424</issn><issn>1091-6490</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1997</creationdate><recordtype>article</recordtype><recordid>eNqFkU2r1DAYhYso1_HqXgQxuBA3HfPdBtyUwS8YcOG9bkOaJm3GTlOTVL3_3owzjF4XukkI5zkvJ-8piscIrhGsyKt5UnEt6BqJ_Ka8ulOsEBSo5FTAu8UKQlyVNcX0fvEgxh2EULAaXhQXAguKCV0VfQNmH6NrRwOCz4f1AXxxeawpVYxeO5VMB-bgk3ETmAcf50GlLIP8TIMBTVCt6_wcXQSbbfO5uWoQiK6f1OimHswqDd_VzcPinlVjNI9O92Vx_fbN1eZ9uf347sOm2ZaaUZbKGmmGsMWqrXEHhaKWdoS2tcC4EsJyymzLNaprjTvMbFcxBY3AmhnINeeUXBavj3Pnpd2bTpspBTXKObi9CjfSKydvK5MbZO-_SUxIzbP9xcke_NfFxCT3LmozjmoyfomyEjkHyZv_H4h4roGyQ6Dnf4E7v4S8nCgxRFhwWsMMwSOkQy4jGHsOjKA8FC0PRUtBJRLyV9HZ8vTPj54Np2az_uykH5xn9daEl_8mpF3GMZkfKaNPjuguJh_OLCWYwN9JrPJS9cFFef0JCVHBCnKGyE-_rs9D</recordid><startdate>19970916</startdate><enddate>19970916</enddate><creator>Williams, R.W</creator><creator>Wilson, J.M</creator><creator>Meyerowitz, E.M</creator><general>National Academy of Sciences of the United States of America</general><general>National Acad Sciences</general><general>National Academy of Sciences</general><general>The National Academy of Sciences of the USA</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QG</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>7TO</scope><scope>7U9</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>M7N</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>19970916</creationdate><title>A possible role for kinase-associated protein phosphatase in the Arabidopsis CLAVATA1 signaling pathway</title><author>Williams, R.W ; Wilson, J.M ; Meyerowitz, E.M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c545t-81c512f2ab82d09a4f4d34b8922799f645fb6c188c2d25fd75a0e92c5e06c6643</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1997</creationdate><topic>ACTIVIDAD ENZIMATICA</topic><topic>ACTIVITE ENZYMATIQUE</topic><topic>Alleles</topic><topic>Amino acids</topic><topic>APICAL MERISTEMS</topic><topic>Arabidopsis</topic><topic>Arabidopsis - enzymology</topic><topic>Arabidopsis Proteins</topic><topic>ARABIDOPSIS THALIANA</topic><topic>ARN MENSAJERO</topic><topic>ARN MESSAGER</topic><topic>AUTOPHOSPHORYLATION</topic><topic>Biological Sciences</topic><topic>Botany</topic><topic>Carpels</topic><topic>Enzymes</topic><topic>ENZYMIC ACTIVITY</topic><topic>ESTERASAS</topic><topic>ESTERASE</topic><topic>ESTERASES</topic><topic>EXPRESION GENICA</topic><topic>EXPRESSION DES GENES</topic><topic>FLEUR</topic><topic>FLORES</topic><topic>FLOWERS</topic><topic>FOSFORILACION</topic><topic>GENE</topic><topic>GENE EXPRESSION</topic><topic>Gene Expression Regulation, Plant</topic><topic>GENES</topic><topic>INFLORESCENCE MERISTEMS</topic><topic>KAPP GENE</topic><topic>MERISTEMAS</topic><topic>MERISTEMAS APICALES</topic><topic>MERISTEME</topic><topic>MERISTEME APICAL</topic><topic>MERISTEMS</topic><topic>MESSENGER RNA</topic><topic>Phenotypes</topic><topic>Phosphatases</topic><topic>PHOSPHOPROTEIN PHOSPHATASE</topic><topic>Phosphoprotein Phosphatases - genetics</topic><topic>Phosphoprotein Phosphatases - metabolism</topic><topic>PHOSPHORYLATION</topic><topic>PLANTAS TRANSGENICAS</topic><topic>PLANTE TRANSGENIQUE</topic><topic>Plants</topic><topic>Plants, Genetically Modified</topic><topic>Protein Binding</topic><topic>PROTEIN KINASE</topic><topic>PROTEINA QUINASA</topic><topic>PROTEINE KINASE</topic><topic>Regulator genes</topic><topic>RNA</topic><topic>RNA, Messenger - genetics</topic><topic>Signal Transduction</topic><topic>STRUCTURAL GENES</topic><topic>TRANSGENIC PLANTS</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Williams, R.W</creatorcontrib><creatorcontrib>Wilson, J.M</creatorcontrib><creatorcontrib>Meyerowitz, E.M</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Animal Behavior Abstracts</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Williams, R.W</au><au>Wilson, J.M</au><au>Meyerowitz, E.M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A possible role for kinase-associated protein phosphatase in the Arabidopsis CLAVATA1 signaling pathway</atitle><jtitle>Proceedings of the National Academy of Sciences - PNAS</jtitle><addtitle>Proc Natl Acad Sci U S A</addtitle><date>1997-09-16</date><risdate>1997</risdate><volume>94</volume><issue>19</issue><spage>10467</spage><epage>10472</epage><pages>10467-10472</pages><issn>0027-8424</issn><eissn>1091-6490</eissn><abstract>Continuous growth and development in plants are accomplished by meristems, groups of undifferentiated cells that persist as stem cells and initiate organs. While the structures of the apical and floral meristems in dicotyledonous plants have been well described, little is known about the underlying molecular mechanisms controlling cell proliferation and differentiation in these structures. We have shown previously that the CLAVATA1 (CLV1) gene in Arabidopsis encodes a receptor kinase-like protein that controls the size of the apical and floral meristems. Here, we show that KAPP, a gene encoding a kinase-associated protein phosphatase, is expressed in apical and young floral meristems, along with CLV1. Overexpression of KAPP mimics the clv1 mutant phenotype. Furthermore, CLV1 has kinase activity: it phosphorylates both itself and KAPP. Finally, KAPP binds and dephosphorylates CLV1. We present a model where KAPP functions as a negative regulator of the CLAVATA1 signal transduction pathway</abstract><cop>United States</cop><pub>National Academy of Sciences of the United States of America</pub><pmid>9294234</pmid><doi>10.1073/pnas.94.19.10467</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 0027-8424 |
| ispartof | Proceedings of the National Academy of Sciences - PNAS, 1997-09, Vol.94 (19), p.10467-10472 |
| issn | 0027-8424 1091-6490 |
| language | eng |
| recordid | cdi_pnas_primary_94_19_10467 |
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| subjects | ACTIVIDAD ENZIMATICA ACTIVITE ENZYMATIQUE Alleles Amino acids APICAL MERISTEMS Arabidopsis Arabidopsis - enzymology Arabidopsis Proteins ARABIDOPSIS THALIANA ARN MENSAJERO ARN MESSAGER AUTOPHOSPHORYLATION Biological Sciences Botany Carpels Enzymes ENZYMIC ACTIVITY ESTERASAS ESTERASE ESTERASES EXPRESION GENICA EXPRESSION DES GENES FLEUR FLORES FLOWERS FOSFORILACION GENE GENE EXPRESSION Gene Expression Regulation, Plant GENES INFLORESCENCE MERISTEMS KAPP GENE MERISTEMAS MERISTEMAS APICALES MERISTEME MERISTEME APICAL MERISTEMS MESSENGER RNA Phenotypes Phosphatases PHOSPHOPROTEIN PHOSPHATASE Phosphoprotein Phosphatases - genetics Phosphoprotein Phosphatases - metabolism PHOSPHORYLATION PLANTAS TRANSGENICAS PLANTE TRANSGENIQUE Plants Plants, Genetically Modified Protein Binding PROTEIN KINASE PROTEINA QUINASA PROTEINE KINASE Regulator genes RNA RNA, Messenger - genetics Signal Transduction STRUCTURAL GENES TRANSGENIC PLANTS |
| title | A possible role for kinase-associated protein phosphatase in the Arabidopsis CLAVATA1 signaling pathway |
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