Yersinia enterocolitica Induces Apoptosis in Macrophages by a Process Requiring Functional Type III Secretion and Translocation Mechanisms and Involving YopP, Presumably Acting as an Effector Protein

Yersiniae, causative agents of plague and gastrointestinal diseases, secrete and translocate Yop effector proteins into the cytosol of macrophages, leading to disruption of host defense mechanisms. It is shown in this report that Yersinia enterocolitica induces apoptosis in macrophages and that this...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1997-11, Vol.94 (23), p.12638-12643
Main Authors: Mills, Scott D., Boland, Anne, Sory, Marie-Paule, Van Der Smissen, Patrick, Kerbourch, Corinne, Finlay, B. Brett, Cornelis, Guy R.
Format: Article
Language:English
Subjects:
Amino Acid Sequence
Animals
Apoptosis
Bacteria
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
Biological Sciences
Cell Line
Cell lines
Cell nucleus
Epithelial cells
HeLa cells
Infections
Macrophages
Macrophages - microbiology
Macrophages - pathology
Mice
Microbiology
Molecular Sequence Data
Proteins
Rodents
Secretion
Yersinia
Yersinia enterocolitica
Yersinia Infections - metabolism
Yersinia Infections - pathology
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Summary:Yersiniae, causative agents of plague and gastrointestinal diseases, secrete and translocate Yop effector proteins into the cytosol of macrophages, leading to disruption of host defense mechanisms. It is shown in this report that Yersinia enterocolitica induces apoptosis in macrophages and that this effect depends on YopP. Functional secretion and translocation mechanisms are required for YopP to act, strongly suggesting that this protein exerts its effect intracellularly, after translocation into the macrophages. YopP shows a high level of sequence similarity with AvrRxv, an avirulence protein from Xanthomonas campestris, a plant pathogen that induces programmed cell death in plant cells. This indicates possible similarities between the strategies used by pathogenic bacteria to elicit programmed cell death in both plant and animal hosts.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.94.23.12638