Regulation of Vascular Endothelial Growth Factor Production and Angiogenesis by the Cytoplasmic Tail of Tissue Factor

Tissue factor (TF), a transmembrane receptor for coagulation factor VII/VIIa, is aberrantly expressed in human cancers. We demonstrated a significant correlation between TF and vascular endothelial growth factor (VEGF) production in 13 human malignant melanoma cell lines (r2 = 0.869, $P

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1999-07, Vol.96 (15), p.8663-8668
Main Authors: Abe, Keisuke, Shoji, Mamoru, Chen, Jiang, Bierhaus, Angelika, Danave, Indrani, Micko, Cornelia, Casper, Katherine, Dillehay, Dirck L., Nawroth, Peter P., Rickles, Frederick R.
Format: Article
Language:English
Subjects:
Angiogenesis
Animals
Antibodies
Biological Sciences
Cell lines
Cells
Complementary DNA
Cultured cells
Endothelial Growth Factors - genetics
Endothelial Growth Factors - metabolism
Endothelium, Vascular - cytology
Gene Expression Regulation, Neoplastic
Humans
Immunohistochemistry
Lymphokines - genetics
Lymphokines - metabolism
Medical research
Melanoma
Melanoma - genetics
Mice
Mice, SCID
Neoplasm Transplantation
Neovascularization, Pathologic - genetics
Plasmids
RNA, Messenger - metabolism
Sequence Deletion
Thromboplastin - genetics
Thromboplastin - metabolism
Transfection
Tumor cell line
Tumor Cells, Cultured
Tumors
Vascular Endothelial Growth Factor A
Vascular Endothelial Growth Factors
von Willebrand Factor - immunology
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Description
Summary:Tissue factor (TF), a transmembrane receptor for coagulation factor VII/VIIa, is aberrantly expressed in human cancers. We demonstrated a significant correlation between TF and vascular endothelial growth factor (VEGF) production in 13 human malignant melanoma cell lines (r2 = 0.869, $P
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.96.15.8663