The Dimensions of the Protein Import Channels in the Outer and Inner Mitochondrial Membranes

Most mitochondrial proteins are imported into mitochondria through transmembrane channels composed largely, and perhaps exclusively, of proteins. We have determined the effective internal diameter of the protein import channel in the mitochondrial outer membrane to be between 20 angstrom and 26 angs...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1999-11, Vol.96 (23), p.13086-13090
Main Authors: Schwartz, Michael P., Matouschek, Andreas
Format: Article
Language:English
Subjects:
Biochemistry
Biological Sciences
Biological Transport
Genetic mutation
Imports
Intracellular Membranes - metabolism
Membrane proteins
Membranes
Mitochondria
Mitochondria - metabolism
Mitochondrial membranes
P branes
Protein precursors
Proteins
Proteins - metabolism
Saccharomyces cerevisiae - metabolism
String theory
Transfer RNA
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Summary:Most mitochondrial proteins are imported into mitochondria through transmembrane channels composed largely, and perhaps exclusively, of proteins. We have determined the effective internal diameter of the protein import channel in the mitochondrial outer membrane to be between 20 angstrom and 26 angstrom during translocation. The diameter of the import channel in the inner membrane is smaller than the diameter of the outer membrane import channel. These results were obtained by measuring the effect of rigid steric bulk introduced into precursor proteins on import.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.96.23.13086