Histone, modification governs the cell cycle regulation of a replication-independent chromatin assembly pathway in Saccharomyces cerevisiae

We describe a replication-independent, cell cycle-regulated chromatin assembly pathway in budding yeast. The activity of this pathway is low in S phase extracts but is very high in G2, M, and G1 cell extracts, with peak activity in late M/early G1. The cell cycle regulation of this pathway requires...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1999-02, Vol.96 (4), p.1345-1350
Main Authors: Altheim, B.A. (University of Alberta, Canada.), Schultz, M.C
Format: Article
Language:English
Subjects:
Biochemistry
Biological Sciences
Cell cycle
Cell Cycle - physiology
Cell cycle proteins
CELL DIVISION
Cell extracts
CHEMICAL REACTIONS
CHROMATIN
Chromatin - physiology
CHROMATINE
CROMATINA
DIVISION CELLULAIRE
DIVISION CELULAR
DNA REPLICATION
Flow Cytometry
G1 Phase
G2 Phase
Gene expression regulation
HISTONAS
HISTONE
HISTONES
Histones - metabolism
INTERPHASE
Kinetics
MITOSE
MITOSIS
Nucleosomes
POSTTRANSLATIONAL MODIFICATION
Protein Processing, Post-Translational
REACCIONES QUIMICAS
REACTION CHIMIQUE
REPLICACION
REPLICATION
SACCHAROMYCES CEREVISIAE
Saccharomyces cerevisiae - cytology
Saccharomyces cerevisiae - genetics
Saccharomyces cerevisiae - physiology
Time Factors
Yeasts
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Summary:We describe a replication-independent, cell cycle-regulated chromatin assembly pathway in budding yeast. The activity of this pathway is low in S phase extracts but is very high in G2, M, and G1 cell extracts, with peak activity in late M/early G1. The cell cycle regulation of this pathway requires a specific pattern of posttranslational modification of histones H3 and/or H4, which is distinct for H3/H4 present in S phase versus M and G1 phase cell extracts. Histone H3/H4 modification is therefore important for the reciprocal control of replication-dependent and -independent chromatin assembly pathways during the cell cycle
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.96.4.1345