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Caspase-10 is an Initiator Caspase in Death Receptor Signaling

A role for caspase-10, previously implicated in the autoimmune lymphoproliferative syndrome, in death receptor signaling has not been directly shown. Here we show that caspase-10 can function independently of caspase-8 in initiating Fas- and tumor necrosis factor-related apoptosis-inducing ligand-re...

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Published in:Proceedings of the National Academy of Sciences - PNAS 2001-11, Vol.98 (24), p.13884-13888
Main Authors: Wang, Jin, Chun, Hyung J., Wong, Wilson, Spencer, David M., Lenardo, Michael J.
Format: Article
Language:English
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Summary:A role for caspase-10, previously implicated in the autoimmune lymphoproliferative syndrome, in death receptor signaling has not been directly shown. Here we show that caspase-10 can function independently of caspase-8 in initiating Fas- and tumor necrosis factor-related apoptosis-inducing ligand-receptor-mediated apoptosis. Moreover, Fas crosslinking in primary human T cells leads to the recruitment and activation of caspase-10. Fluorescent resonance energy transfer analysis indicates that the death-effector domains of caspase-8 and -10 both interact with the death-effector domain of FADD. Nonetheless, we find that caspase-8 and -10 may have different apoptosis substrates and therefore potentially distinct roles in death receptor signaling or other cellular processes.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.241358198