A Highly Ca2+-Sensitive Pool of Vesicles Is Regulated by Protein Kinase C in Adrenal Chromaffin Cells

We have used flash photolysis of caged Ca2+and membrane capacitance measurements to probe exocytosis in chromaffin cells at low concentrations of intracellular Ca2+([Ca2+]i) (

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2002-12, Vol.99 (26), p.17060-17065
Main Authors: Yang, Yan, Udayasankar, Sangeetha, Dunning, James, Chen, Peng, Gillis, Kevin D.
Format: Article
Language:English
Subjects:
Animals
Biological Sciences
Calcium
Calcium - metabolism
Calcium Channels - physiology
Capacitance
Cattle
Cells
Cells, Cultured
Chromaffin cells
Chromaffin Cells - metabolism
Depolarization
Enzyme Activation
Exocytosis
Kinetics
Membrane Proteins - physiology
Nerve Tissue Proteins - physiology
Neurology
Neurons
Neuroscience
Photolysis
Pipettes
Protein Kinase C - physiology
Proteins
Secretory Vesicles - metabolism
Synaptosomal-Associated Protein 25
Tetradecanoylphorbol Acetate - pharmacology
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Description
Summary:We have used flash photolysis of caged Ca2+and membrane capacitance measurements to probe exocytosis in chromaffin cells at low concentrations of intracellular Ca2+([Ca2+]i) (
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.242624699