Overhauser Enhanced Magnetic Resonance Imaging for Tumor Oximetry: Coregistration of Tumor Anatomy and Tissue Oxygen Concentration

An efficient noninvasive method for in vivo imaging of tumor oxygenation by using a low-field magnetic resonance scanner and a paramagnetic contrast agent is described. The methodology is based on Overhauser enhanced magnetic resonance imaging (OMRI), a functional imaging technique. OMRI experiments...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2002-02, Vol.99 (4), p.2216-2221
Main Authors: Krishna, Murali C., English, Sean, Yamada, Kenichi, Yoo, John, Murugesan, Ramachandran, Devasahayam, Nallathamby, Cook, John A., Golman, Klaes, Ardenkjaer-Larsen, Jan Henrik, Subramanian, Sankaran, Mitchell, James B.
Format: Article
Language:English
Subjects:
Air
Algorithms
Anatomy
Animals
Biological Sciences
Breathing
Contrast Media - pharmacology
Dose-Response Relationship, Drug
Female
Hypoxia
Image Processing, Computer-Assisted
Imaging
Irradiation
Magnetic Resonance Imaging - methods
Medical research
Methods
Mice
Mice, Inbred C3H
Neoplasm Transplantation
Neoplasms - diagnosis
Neoplasms - metabolism
NMR
Nuclear magnetic resonance
Oxygen
Oxygen - metabolism
Oxygen Consumption
Supernova remnants
Tissue oxygenation
Tumors
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Summary:An efficient noninvasive method for in vivo imaging of tumor oxygenation by using a low-field magnetic resonance scanner and a paramagnetic contrast agent is described. The methodology is based on Overhauser enhanced magnetic resonance imaging (OMRI), a functional imaging technique. OMRI experiments were performed on tumor-bearing mice (squamous cell carcinoma) by i.v. administration of the contrast agent Oxo63 (a highly derivatized triarylmethyl radical) at nontoxic doses in the range of 2-7 mmol/kg either as a bolus or as a continuous infusion. Spatially resolved pO2(oxygen concentration) images from OMRI experiments of tumor-bearing mice exhibited heterogeneous oxygenation profiles and revealed regions of hypoxia in tumors (
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.042671399