A comparison of hypotension and bradycardia following spinal anesthesia in patients on calcium channel blockers and [beta]-blockers

Objectives: Hypotension is a common complication of spinal anesthesia and is frequent in patients with hypertension. Antihypertensive agents decrease this effect by controlling blood pressure. There are conflicting reports on the continuation of antihypertensive drugs on the day of surgery in patien...

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Bibliographic Details
Published in:Indian journal of pharmacology 2012-03, Vol.44 (2), p.193
Main Authors: Kaimar, Padmanabha, Sanji, Narendranath, Upadya, Madhusudan, Mohammed, K
Format: Article
Language:English
Subjects:
Adrenergic beta blockers
Anesthesia
Beta blockers
Blood pressure
Bradycardia
Calcium channel blockers
Cardiac arrhythmia
Comparative analysis
Development and progression
Health aspects
Hypotension
Pharmacology
Physiological aspects
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Summary:Objectives: Hypotension is a common complication of spinal anesthesia and is frequent in patients with hypertension. Antihypertensive agents decrease this effect by controlling blood pressure. There are conflicting reports on the continuation of antihypertensive drugs on the day of surgery in patients undergoing spinal anesthesia. Sudden hypotension could have detrimental effect on the organ systems. This study was undertaken to compare the variation in blood pressure in hypertensive patients on β-blockers and calcium channel blockers undergoing spinal anesthesia. Materials and Methods: Ninety patients were enrolled for the study, 30 each in the control, β-blocker and the calcium channel blocker groups. Results: The incidence of hypotension was not different among the three groups. However, the number of times mephentermine used to treat hypotension was significant in the patients receiving calcium channel blockers while incidence of bradycardia in patients treated with β-blockers was significant (P
ISSN:0253-7613
1998-3751
DOI:10.4103/0253-7613.93847