Therapeutic Liposomal Dry Powder Inhalation Aerosols for Targeted Lung Delivery

Therapeutic liposomal powders (i.e., lipospheres and proliposomes) for dry powder inhalation aerosol delivery, formulated with phospholipids similar to endogenous lung surfactant, offer unique opportunities in pulmonary nanomedicine while offering controlled release and enhanced stability. Many pulm...

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Bibliographic Details
Published in:Lung 2012-06, Vol.190 (3), p.251-262
Main Authors: Willis, Lauren, Hayes, Don, Mansour, Heidi M.
Format: Article
Language:English
Subjects:
Administration, Inhalation
Aerosols
Asthma
Cystic fibrosis
Drug delivery systems
Drugs
Health aspects
Humans
Lipids
Liposomes
Lung - metabolism
Lung cancer
Lung diseases
Lung Diseases - drug therapy
Medicine
Medicine & Public Health
Nanocapsules
Nanoparticles
Pharmaceutical Preparations - administration & dosage
Pneumology/Respiratory System
Powders
Respiratory agents
Respiratory therapy
Surface active agents
Vehicles
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Description
Summary:Therapeutic liposomal powders (i.e., lipospheres and proliposomes) for dry powder inhalation aerosol delivery, formulated with phospholipids similar to endogenous lung surfactant, offer unique opportunities in pulmonary nanomedicine while offering controlled release and enhanced stability. Many pulmonary diseases such as lung cancer, tuberculosis (TB), cystic fibrosis (CF), bacterial and fungal lung infections, asthma, and chronic obstructive pulmonary disease (COPD) could greatly benefit from this type of pulmonary nanomedicine approach that can be delivered in a targeted manner by dry powder inhalers (DPIs). These delivery systems may require smaller doses for efficacy, exhibit reduced toxicity, fewer side effects, controlled drug release over a prolonged time period, and increased formulation stability as inhaled powders. This state-of-the-art review presents these novel aspects in depth.
ISSN:0341-2040
1432-1750
DOI:10.1007/s00408-011-9360-x