Serotonin syndrome due to an overdose of moclobemide and clomipramine : A potentially life-threatening association

The serotonin syndrome is frequently characterized by minor neurologic manifestations that regress rapidly (such as confusion, tremor, ...). Many medications including tricyclic antidepressants, serotonin reuptake inhibitors, tryptophan and the association of monoamine oxidase inhibitors together wi...

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Bibliographic Details
Published in:Intensive care medicine 1997, Vol.23 (1), p.122-124
Main Authors: FRANCOIS, B, MARQUET, P, DESACHY, A, ROUSTAN, J, LACHATRE, G, GASTINNE, H
Format: Article
Language:English
Subjects:
Antidepressive Agents - poisoning
Antipsychotics
Benzamides - poisoning
Biological and medical sciences
Clomipramine - poisoning
Coma
Dialysate
Drug Interactions
Drug intoxications. Doping
Drug Overdose
Female
Hemodialysis
Humans
Hyperthermia
Intensive care
Medical sciences
Middle Aged
Moclobemide
Monoamine Oxidase Inhibitors - poisoning
Pharmacology. Drug treatments
Rhabdomyolysis
Serotonin
Serotonin - metabolism
Serotonin Uptake Inhibitors - poisoning
Syndrome
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Summary:The serotonin syndrome is frequently characterized by minor neurologic manifestations that regress rapidly (such as confusion, tremor, ...). Many medications including tricyclic antidepressants, serotonin reuptake inhibitors, tryptophan and the association of monoamine oxidase inhibitors together with a serotoninergic agent have been implicated in this syndrome. In certain cases, and for poorly understood reasons, clinical manifestations can include circulatory collapse, malignant hyperthermia, convulsions and rhabdomyolysis. These forms are often fatal. Treatment, other than the withdrawal of the offending drug, is symptomatic. Dialysis may be of value in withdrawing the drug from the circulatory system. We report a patient with the serotonin syndrome of favorable outcome due to an overdose of moclobemide and clomipramine.
ISSN:0342-4642
1432-1238
DOI:10.1007/s001340050303