Steroid-induced insulin resistance and impaired glucose tolerance are both associated with a progressive decline of incretin effect in first-degree relatives of patients with type 2 diabetes

Aims/hypothesis The aim of this study was to evaluate the separate impact of insulin resistance and impaired glucose tolerance (IGT) on the incretin effect. Methods Twenty-one healthy glucose-tolerant first-degree relatives of patients with type 2 diabetes underwent a 75 g OGTT, an isoglycaemic i.v....

Full description

Saved in:
Bibliographic Details
Published in:Diabetologia 2012-05, Vol.55 (5), p.1406-1416
Main Authors: Jensen, D. H., Aaboe, K., Henriksen, J. E., Vølund, A., Holst, J. J., Madsbad, S., Krarup, T.
Format: Article
Language:English
Subjects:
Adult
Biological and medical sciences
Blood Glucose - drug effects
Dexamethasone - pharmacology
Diabetes
Diabetes. Impaired glucose tolerance
Endocrine pancreas. Apud cells (diseases)
Endocrinology
Endocrinopathies
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Female
Glucagon
Glucocorticoids - pharmacology
Glucose
Glucose Intolerance - chemically induced
Glucose Intolerance - metabolism
Glucose Tolerance Test
Hormones
Human Physiology
Humans
Incretins - blood
Incretins - metabolism
Insulin resistance
Insulin Resistance - physiology
Internal Medicine
Male
Medical sciences
Medicine
Medicine & Public Health
Metabolic Diseases
Peptides
Registration
Steroids
Young Adult
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Aims/hypothesis The aim of this study was to evaluate the separate impact of insulin resistance and impaired glucose tolerance (IGT) on the incretin effect. Methods Twenty-one healthy glucose-tolerant first-degree relatives of patients with type 2 diabetes underwent a 75 g OGTT, an isoglycaemic i.v. glucose test and a mixed meal to evaluate the incretin effect before and after treatment with dexamethasone to increase insulin resistance. Beta cell glucose sensitivity, beta cell index and fasting proinsulin were measured as indices of beta cell function. Results After dexamethasone, ten individuals had increased insulin resistance but normal glucose tolerance (NGT), while 11 individuals with an equal increase in insulin resistance developed IGT. In the NGT and IGT groups, the incretin effects were 71 ± 3.2% and 67 ± 4.6% ( p  = 0.4) before treatment, but decreased significantly in both groups to 58 ± 5.2% and 32 ± 8.8% ( p  
ISSN:0012-186X
1432-0428
DOI:10.1007/s00125-012-2459-7