Interactions between metals in rat liver and kidney: localization of metallothionein

The interactions between two essential metals, Cu and Zn, and the localization and concentration of metallothionein have been studied in rat liver and kidney. Rats receiving daily intraperitoneal injections of Cu for 3 days, or Zn for 2 days, or Cu for 3 days followed by Zn for 2 days, were sacrific...

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Bibliographic Details
Published in:Journal of molecular histology 2001-02, Vol.33 (2), p.79
Main Authors: Irato, P, Santon, A, Ossi, E, Albergoni, V
Format: Article
Language:English
Subjects:
Animals
Copper - administration & dosage
Copper - metabolism
Drug Synergism
Immunohistochemistry
Kidney - drug effects
Kidney - metabolism
Liver
Liver - drug effects
Liver - metabolism
Male
Metallothionein - metabolism
Microscopy, Fluorescence
Rats
Rodents
Zinc - administration & dosage
Zinc - metabolism
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Summary:The interactions between two essential metals, Cu and Zn, and the localization and concentration of metallothionein have been studied in rat liver and kidney. Rats receiving daily intraperitoneal injections of Cu for 3 days, or Zn for 2 days, or Cu for 3 days followed by Zn for 2 days, were sacrificed 24, 72, 120 h after the final injection. Our data indicate that Cu and Zn are both good inductors of metallothionein synthesis in rat tissues. Synergism between Cu and Zn in metallothionein synthesis was also observed as indicated by immunocytochemical experiments and chemical analysis. Moreover, in rats injected with Cu followed by Zn, the localization of metallothionein and the concentrations of both metallothionein and metal differed over time according to the organs considered. In rat kidney, a delay in the excretory process was also observed and metallothionein was present 120 h after the last injection.
ISSN:0018-2214
1567-2379
1567-2387
DOI:10.1023/A:1017944129801