Prognostic factors in a series of 504 breast cancer patients with metastatic spinal cord compression

Background This study was performed to identify new significant prognostic factors in breast cancer patients irradiated for metastatic spinal cord compression (MSCC). Patients and methods The data of 504 patients with breast cancer patients with MSCC were retrospectively analyzed with respect to pos...

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Bibliographic Details
Published in:Strahlentherapie und Onkologie 2012-04, Vol.188 (4), p.340-345
Main Authors: Rades, D., Douglas, S., Veninga, T., Stalpers, L.J.A., Bajrovic, A., Rudat, V., Schild, S.E.
Format: Article
Language:English
Subjects:
Activities of Daily Living - classification
Aged
Antiemetics - administration & dosage
Breast Neoplasms - radiotherapy
Cohort Studies
Dexamethasone - administration & dosage
Female
Follow-Up Studies
Humans
Kaplan-Meier Estimate
Lumbar Vertebrae - radiation effects
Magnetic Resonance Imaging
Medicine
Medicine & Public Health
Middle Aged
Mobility Limitation
Multivariate Analysis
Neoplasm Staging
Neurologic Examination - radiation effects
Oncology
Original Article
Prognosis
Proportional Hazards Models
Radiotherapy
Retrospective Studies
Spinal Cord Compression - mortality
Spinal Cord Compression - pathology
Spinal Cord Compression - radiotherapy
Spinal Neoplasms - mortality
Spinal Neoplasms - pathology
Spinal Neoplasms - radiotherapy
Spinal Neoplasms - secondary
Survival Analysis
Thoracic Vertebrae - radiation effects
Tomography, X-Ray Computed
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Summary:Background This study was performed to identify new significant prognostic factors in breast cancer patients irradiated for metastatic spinal cord compression (MSCC). Patients and methods The data of 504 patients with breast cancer patients with MSCC were retrospectively analyzed with respect to posttreatment motor function, local control of MSCC, and survival. The investigated potential prognostic factors included age, Eastern Cooperative Oncology Group (ECOG) performance score, number of involved vertebrae, other bone metastases, visceral metastases, pretreatment ambulatory status, interval from cancer diagnosis to radiotherapy of MSCC, time developing motor deficits before radiotherapy, and the radiation schedule. Results On multivariate analysis, better functional outcome was associated with ambulatory status prior to RT (estimate − 1.29, p 
ISSN:0179-7158
1439-099X
DOI:10.1007/s00066-011-0061-4