Pitfalls in radiation oncology

Positron emission tomography-computed tomography (PET-CT) is a useful diagnostic tool to detect metastases in patients with malignancy. False positives have been reported in cases of inflammation and tissue regeneration. Over a period of 2 years, a 32-year-old woman with hepatocellular carcinoma and...

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Bibliographic Details
Published in:Strahlentherapie und Onkologie 2012-04, Vol.188 (4), p.359
Main Authors: Kröpil, P, Budach, W, Bölke, E, Gerber, Pa, Zinnmann, F, Hautzel, H, Antoch, G, Scherer, A, Matuschek, C
Format: Article
Language:English
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Summary:Positron emission tomography-computed tomography (PET-CT) is a useful diagnostic tool to detect metastases in patients with malignancy. False positives have been reported in cases of inflammation and tissue regeneration. Over a period of 2 years, a 32-year-old woman with hepatocellular carcinoma and multiple bone metastases received three treatments of radiation therapy to a bone metastasis in the 5th left rib. Restaging with [18F]fluorodeoxyglucose (FDG) PET-CT showed increased uptake within the cardiac apex highly suspicious for a myocardial metastasis. Because the patient was asymptomatic, additional magnetic resonance imaging (MRI) of the heart was performed demonstrating radiation-associated changes but no evidence for metastases. PET-CT is a well-established diagnostic tool in metastatic diseases but its results should always be correlated with the clinical picture of the patient and previous treatments to rule out false positives.[PUBLICATION ABSTRACT]
ISSN:0179-7158
1439-099X
DOI:10.1007/s00066-011-0059-y