Mesenchymal stromal cells (MSCs): science and f(r)iction

Due to their multi-lineage differentiation capacity, support of haematopoiesis, immunomodulation and secretion of proregenerative factors, mesenchymal stem/stromal cells (MSCs) are in the focus of intense research since decades. The literature is replete with reports on their potential in preclinica...

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Bibliographic Details
Published in:Journal of molecular medicine (Berlin, Germany) Germany), 2012-07, Vol.90 (7), p.773-782
Main Authors: Bieback, Karen, Wuchter, Patrick, Besser, Daniel, Franke, Werner, Becker, Matthias, Ott, Michael, Pacher, Martin, Ma, Nan, Stamm, Christof, Klüter, Harald, Müller, Albrecht, Ho, Anthony D.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Cell Differentiation
Cell- and Tissue-Based Therapy
Hematopoiesis
Hepatocytes - cytology
Human Genetics
Humans
Immunomodulation
Induced Pluripotent Stem Cells
Internal Medicine
Mesenchymal Stem Cell Transplantation
Mesenchymal Stromal Cells - cytology
Mesenchymal Stromal Cells - metabolism
Molecular Medicine
Myocytes, Cardiac - cytology
Quality Control
Review
Citations: Items that this one cites
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Summary:Due to their multi-lineage differentiation capacity, support of haematopoiesis, immunomodulation and secretion of proregenerative factors, mesenchymal stem/stromal cells (MSCs) are in the focus of intense research since decades. The literature is replete with reports on their potential in preclinical model systems. However, the heterogeneity of the primary cell population as starting material and the diverse protocols for isolation and cultivation are hampering progress in their clinical application. Consensus on common standards and harmonised isolation and characterisation protocols are important to ensure safety and efficacy. This review focuses on the recent scientific evidence of clinically relevant properties and on the speculative cardiomyogenic and hepatic differentiation potential of MSCs. Special emphasis is put on the importance of standardisation and harmonisation in clinical-scale manufacturing.
ISSN:0946-2716
1432-1440
DOI:10.1007/s00109-012-0915-y