Fluorescence Lifetime Spectroscopy and Imaging in Neurosurgery

Clinical outcome of patients diagnosed with primary brain tumor has been correlated with the extent of surgical resection. In treating this disease, the neurosurgeon must balance between an aggressive, radical resection and minimizing the loss of healthy, functionally significant brain tissue. Numer...

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Bibliographic Details
Published in:IEEE journal of selected topics in quantum electronics 2012-07, Vol.18 (4), p.1465-1477
Main Authors: Marcu, L., Hartl, B. A.
Format: Article
Language:English
Subjects:
Autofluorescence
Brain
brain tumor
Correlation
Fluorescence
glioma
Image resolution
imaging
Instruments
Magnetic resonance imaging
neurosurgery
Quantum electronics
Radicals
Spectroscopy
Surgery
Tumors
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Summary:Clinical outcome of patients diagnosed with primary brain tumor has been correlated with the extent of surgical resection. In treating this disease, the neurosurgeon must balance between an aggressive, radical resection and minimizing the loss of healthy, functionally significant brain tissue. Numerous intraoperative methodologies and technological approaches have been explored as a means to improve the accuracy of surgical resection. This paper presents an overview of current conventional techniques and new emerging technologies with potential to impact the area of image-guided surgery of brain tumors. Emphasis is placed on techniques based on endogenous fluorescence lifetime contrast and their potential for intraoperative diagnosis of brain tumors.
ISSN:1077-260X
1558-4542
DOI:10.1109/JSTQE.2012.2185823