P-190: The effect of accupril on circadian blood pressure patterns in hypertensive subjects with left ventricle hypertrophy

• Published in: American journal of hypertension 2004-05, Vol.17 (S1), p.103A-103A
• Main Authors: da Costa, Lilian Soares, Sabino, Hugo, Zajdenverg, Ricardo, Neto, Soriano de Carvalho Furtado, Neto, Cantidio Drumond, Jazbik, Antonio
• Format: Article
• Language: English
• Subjects: Ambulatory Blood Pressure Monitoring; Left Ventricular Hypertrophy; Pharmacology Therapy
• ISSN: 0895-7061; 1941-7225
• DOI: 10.1016/j.amjhyper.2004.03.265

Antihypertensive treatment that leads to blood pressure reduction is associated to decreased cardiovascular morbi-mortality. Among the agent that are currently available, it appears that inhibitors of the renin-angiotensin-aldosterone system are most effective. Data indicate that non-dippers with left ventricular hypertrophy (LVH) have an additional factor for cardiovascular events and higher mortality compared with dippers. In order to demonstrate whether one group of these drugs will be effective to restore the circadian blood pressure patterns in non-dippers hypertensive subjects, we select 18 hypertensive aged 40 to 55 years old who present LVH demonstrated by echocardiography measurements. We studied two groups, 10 non-dipper (42±5years) and 8 dippers (44±4years) demonstrated by ambulatory blood pressure monitoring (ABPM). The distribution of age, body mass index, biochemical parameters and daytime systolic and diastolic blood pressure are similar between groups. We demonstrated that non-dippers have higher values of left ventricular mass compared with dippers (p