P-349: Risk factor profile and target organ damage in hypertensive patients with [alpha]1-microglobulinuria

• Published in: American journal of hypertension 2005-05, Vol.18 (S4), p.132A
• Main Authors: Marinakis, Andreas G, Vyssoulis, Gregory P, Karpanou, Eva A, Aznaouridis, Konstantinos A, Zezas, Stefanos G, Dimitrakopoulos, Socrates A, Pietri, Panagiota A, Cokkinos, Dennis V, Stefanadis, Christodoulos I
• Format: Article
• Language: English
• ISSN: 0895-7061; 1941-7225
• DOI: 10.1016/j.amjhyper.2005.03.367

Microalbuminuria (MA) is an independent predictor of cardiovascular risk in hypertensive patients (pts). Alpha1 -microglobulinuria (MGL), a marker of renal tubular damage, is an early sign of nephropathy in pts with diabetes. The aim of the present study was to investigate whether MGL is associated with increased target organ damage in a hypertensive population.We studied 5100 consecutive, untreated pts with uncomplicated, essential hypertension. Complete clinical, laboratory and cardiac ultrasound examination was carried out in all pts, including 24-hour urine collection for measurement of microalbumin and α 1 -microglobulin. The pts were assigned to 4 groups according to their MA and MGL status: MA positive (MA+, >20mg/l) with or without high (>8.5mg/l) MGL (MA+ MGL+ or MA+ MGL-) and MA negative (MA-) with or without MGL (MA- MGL+ or MA- MGL-).In the MA(-) group, the 146 MGL(+) pts had increased systolic BP (165.3 vs 159.3 mmHg, p