P-11: Endothelial function in essential hypertension with and without target organ damage

• Published in: American journal of hypertension 2005-05, Vol.18 (S4), p.13A-13A
• Main Authors: Goren, Or, Wolak, Talya, Levin, Natalya, Hazan-Hallevy, Inbal, Lipovtzky, Tamara, Friger, Michael, Szendro, Gabriel, Paran, Esther
• Format: Article
• Language: English
• Subjects: Endothelial-Dependent Vasodilatation; Nitric Oxide; Target Organ Damage
• ISSN: 0895-7061; 1941-7225; 1879-1905
• DOI: 10.1016/j.amjhyper.2005.03.029

The aim of this study was to compare endothelial function(ED) in patients with treated essential hypertension with and without target organ damage (TOD) and in healthy subjects. ED was assessed in : 20 treated patients with essential hypertension without TOD, 20 treated patients with essential hypertension with involvement of one or more target organs (ischemic heart disease, or cerbrovascular event, or impaired renal function), and 12 healthy subjects. The study group was assessed for endothelium dependent vasodilatation and plasma levels of nitrate. The mean age of the hypertensives without TOD, hypertensives with TOD and the control group was 57, 65 and 43 years old respectively, the percentage of males was 50%, 58% and 48% respectively. The plasma levels of nitrate was lower in both groups of hypertensives compared to the control group, 9.7 mM and 10.2 mM vs 14.2 mM (p=0.002) respectively. The percent of change in the brachial artery diameter after reactive hyperemia was reduced in both groups of hypertensive patients especially in those with TOD 8.5% and 10% versus 18 %(p