P-188: Long-term antiproteinuric effect of an L/N type calcium channel antagonist, cilnidipine

• Published in: American journal of hypertension 2005-05, Vol.18 (S4), p.74A-75A
• Main Authors: Tsuchihashi, Takuya, Onaka, Uran, Ohta, Yuko, Eto, Kimika, Tominaga, Mitsuhiro, Kajioka, Tomoko, Ueno, Michio
• Format: Article
• Language: English
• Subjects: 24-Hour Home Urine Collection; Cilnidipine; Proteinuria
• ISSN: 0895-7061; 1941-7225; 1879-1905
• DOI: 10.1016/j.amjhyper.2005.03.205

We investigated the long-term antiproteinuric effect of an L/N-type calcium channel (Ca) antagonist, cinlidipine in the patients with essential hypertension (EHT). Subjects are 37 EHT patients (61±2(SE) years, 22 females and 15 males). All patients underwent 24-h home urine collection and proved to have proteinuria greater than 0.1 g/day. Cilnidipine at a mean dose of 8 mg was administered to the patients. In 30 patients, cilnidipine was switched from other Ca antagonists including manidipine and amlodipine, while cilnidipine was newly added in the other 7 patients. Seventeen patients have been received either ACE inhibitors (ACEI) or ARBs at least 6 months before the administration of cilnidipine. Blood pressure (BP), blood chemistry and 24-h home urine collection were determined at 6, 12 and 24 months after the administration of cilnidipine. Baseline BP was 142±2/85±1 mmHg. Systolic BP did not change significantly throughout the study, while diastolic BP was significantly lower at 6 months (82±1 mmHg, p