OR-2: Adenoviral leptin as gene therapy for obesity related hypertension

Leptin has been postulated as an important hormone linking obesity with sympathetic activation and hypertension. In a rat model of dietary obesity moderate hyperleptinemia by adenoviral gene transfer has been shown to reverse all the other features of the metabolic syndrome including insulin resista...

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Bibliographic Details
Published in:American journal of hypertension 2002-04, Vol.15 (S3), p.1A-1A
Main Authors: Zhang, Weiguo, Telemaque-Potts, Sabine, Anderson, Paul R., Wang, Zhongyun, An, Jie, Newgard, Chris B., Victor, Ronald G.
Format: Article
Language:English
Subjects:
Diet
Leptin
Obesity
Online Access:Get full text
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Summary:Leptin has been postulated as an important hormone linking obesity with sympathetic activation and hypertension. In a rat model of dietary obesity moderate hyperleptinemia by adenoviral gene transfer has been shown to reverse all the other features of the metabolic syndrome including insulin resistance and glucose intolerance. To determine if leptin improves or worsens hypertension in this model, we measured blood pressure with intraarterial catheters in young male Wistar rats that had been fed for 6 weeks with normal chow or with a 45% fat diet and then infused with adenoviruses containing the leptin gene (AdCMV-lep), or as a control, the β-galactosidase gene (AdCMV-βGAL). Compared with lean rats, fat-fed rats had a higher mean arterial pressure (MAP): 104±2 vs 94±1 mmHg (p
ISSN:0895-7061
1941-7225
1879-1905
DOI:10.1016/S0895-7061(02)02282-3