P-312: GNb3 polymorphism in Korean hypertensive patients and its practical implication for screening candidate patients

• Published in: American journal of hypertension 2002-04, Vol.15 (S3), p.143A-143A
• Main Authors: Choi, IlKuen, Park, Pil S., Rhee, DongKwon, Song, Il, Kang, DaeUck
• Format: Article
• Language: English
• Subjects: Essential Hypertension; GNB3 Gene Polimorphism; Screening Candidate
• ISSN: 0895-7061; 1941-7225; 1879-1905
• DOI: 10.1016/S0895-7061(02)02663-8

The purpose of the study was to evaluate whether genetic factors contribute to essential hypertension. We investigated the association between G-protein beta3 polymorphism, an average of five retinal arterial bifurcation angles, and essential hypertension. We also examined the relationship between the GNb3 825T allele and blood pressure among gender and age group in the Korean population. The practical implication of screening candidate patients before the onset of high blood pressure is examined in the study. The proposed hypothesis states that essential hypertension is a phenotypic variation within a range of possible blood pressure values determined by multiple factors rather than the result of one mechanism. Theoretical work suggests that the narrowing angles of retinal arterial bifurcation are associated with increased circulatory energy cast. It may be related to lower than normal micro-vascular density. Abnormalities of cardiovascular structure are frequently seen in hypertension and that abnormality may precede the onset of high blood pressure. Recent studies have shown that a C825T polymorphism of the gene encoding G protein beta3 sub-unit contributes to the genesis of essential hypertension. However, the link between the gene and blood pressure is not consistently found in different populations. High blood pressure usually develops after the age of 30 in men and after menopause in female. However, most studies are done without considering gender and age group. We explored the study with grouping. An Analysis of Covariance model was adopted to find the relationship between blood pressures, and a candidate gene GNb3 polymorphism and a covariate of average retinal bifurcation angle in a sample of 39 Korean individuals. The retinal vascular geometry was tested using F statistics in the G beta 3-C825T genotypes (CC,CT,TT). Analysis of Variance models were also used to fit systolic and diastolic blood pressures with GNb3 and a categorical dummy age variable split at age 50 in a sample of 129 Korean female (95 individuals over the age of 50 and 34 individuals under the age of 50). Finally, an ANOVA model was used for the 50 Korean males over 30 years old. We observed a smaller retinal vascular network value in the hypertensive group. The retinal vascular asymmetry can be detected in CT and TT of GNb3 genotypes. We found that the GNb3 825T form of the candidate gene was significantly associated with blood pressures in the susceptive hypertension group. O