P-449: The sympathetic nervous system activity, as evaluated by arterial and post-exercise venous cathecolamines, in obese hypertensive patients. Relationship with leptin leves

• Published in: American journal of hypertension 2002-04, Vol.15 (S3), p.194A-194A
• Main Authors: Sanjuliani, A.F., Genelhu-Fagundes, V., Barroso, S.G., Rodrigues, M.L.G., Duarte, A.V.B., Castro, R.S.P., Bazhuni, C.A., Francischetti, E.A.
• Format: Article
• Language: English
• Subjects: Insulin Resistance; Leptin; Sympathetic Nervous Activity
• ISSN: 0895-7061; 1941-7225
• DOI: 10.1016/S0895-7061(02)02800-5

We studied a group of 40 obese hypertensive patients (7 males and 33 females, BMI=35.7±1.1; SBP=160.0±1.8 mmHg; DBP=103.4±0.9mmHg, age 48.7±1.5yrs, in order to investigate the possible pathophysiological relationships of the venous and arterial cathecolamines levels to the lipid profile, blood pressure, leptin and insulin concentrations. Patients admitted to the study were on no drug therapy for at least 2 weeks. Leptin and insulin levels were determined by RIA, and cathecolamines by HPLC. Regression analysis was performed to account co-linearity among variables. Concentrations of venous and arterial epinephrine (E) were 49.5±5.1 and 52.7±5.6 pg/dl, respectively, and venous concentration post-exercise was 53.7±4.0pg/dl. Venous and arterial concentrations of nor-epinephrine (NE) were 186.7±11.9 and 177.8±10.4 pg/dl, respectively, and venous concentration post-exercise was 191.7 ±11.2pg/dl. Concentrations of insulin and leptin were 26.6±3.0 μU/ml and 28.9±2.4 ng/ml, respectively. Glucose, triglycerides (TG), total cholesterol and HDL levels were 102.0±2.84, 161.0±13.7, 222.5± 7.6 and 45.5±2.1mg/dl, respectively. Venous supine NE was positively correlated to leptin levels (r=0.63, p=0.02) and to TG (r =0.39, p < 0.05). Arterial NE concentrations were positively associated to: BMI (r = 0.35, p < 0.05); leptin (r = 0.34, p