P-437: The effects of obesity on leptin, intraerythrocyte sodium and C-reactive protein, on metabolic variables of Brazilian male adolescents

• Published in: American journal of hypertension 2002-04, Vol.15 (S3), p.190A-190A
• Main Authors: Castelli, R.C.R., Genelhu-Fagundes, V., Kaiser, S.E., Farinatti, P.T.V., Rodrigues, M.L.G., Castro, R.P.S., Souza, L.K.C.S., Barroso, S.G., Francischetti, E.A.
• Format: Article
• Language: English
• Subjects: Adolescents; Cardiovascular Risk Factors; Obesity
• ISSN: 0895-7061; 1941-7225
• DOI: 10.1016/S0895-7061(02)02788-7

To study the metabolic and cardiovascular profile in healthy obese male adolescents, comparing to lean individuals, we evaluated in 20 obese male adolescents (age 14.5 ± 2.2 yrs) and 14 lean littermates (age 15.8 ± 2.3 yrs) the anthropometrical measures (waist and hip circumferences and BMI), blood pressure (using the DINAMAP device), intraerythrocyte sodium content (NaIc) (modified Cheng's method), lipid profile, leptin, insulin (RIA), and C-reactive protein (Nephelometric method). We compared the two groups using the T-student test or Fisher's test when appropriate, and the correlations among variables were evaluated by the Pearson's and Spearman's correlation. There were no differences on age and blood pressure between groups (PAM=87.03 ± 3.1 mmHg in obese individuals vs 80.8 ± 3.9 mmHg in control group). Nevertheless we found significant differences in obese and non-obese in the following variables: leptin (17.1± 2.6 vs 7.457 ± 2.7 ng/dl, p