P-356: Nocturnal inappropriate aldosterone activity and reduced potassium balance in salt sensitive hypertensives with blunting of nighttime BP fall

• Published in: American journal of hypertension 2003-05, Vol.16 (S1), p.166A-167A
• Main Authors: Diogo, Domingos, Caupers, Paula, Damasceno, Albertino, Polonia, Jorge
• Format: Article
• Language: English
• Subjects: Mechanisms; Renin angiotensin system; Salt sensitive hypertension
• ISSN: 0895-7061; 1941-7225
• DOI: 10.1016/S0895-7061(03)00521-1

Salt sensitive hypertensives (SSHT) differently from salt-resistants –SR are prone to exhibit a blunted nocturnal BP fall when switching from low to high salt intake. In 10 black SSHTs (ageing 35-64 yrs, 5 male) and in 10 black SRs (ageing 32-60 yrs, 4 male) we examined separately during daytime (6.00-22.00 h) and nighttime (22.00-6.00h), the BP (Spacelabs 90207), the aldosterone activity by measuring plasmatic aldosterone to renin ratio (ARR), and the plasma and urinary sodium, potassium and creatinine values, on the last day of 2x2 weeks on high-sodium diet (HS, 300 mmol Na+/d) and on low salt diet (LS, 20 mmol Na+/d-2 weeks) and after an acute salt load while on LS diet (LS-infusion) (i.v. infusion of 2L NaCl both during daytime and nighttime). On LS, HS and LS-infusion, nighttime/daytime MAP fall (%) were in HTSS of 9.4(1.1) on LS-pl; 3.4(0.9) on HS-pl; and 2.4(1.0) on LS-infusion (p