Loading…

P-537: Pioglitazone blunts the blood pressure response to angiotensin II in insulin-resistant zucker rats

Thiazolidinediones are high-affinity agonists of peroxisome proliferator-activated receptors (PPAR)-γ which have been found to lower blood pressure (BP) in animal models of diabetes and reno-vascular hypertension. The mechanisms leading to this decrease in blood pressure are still unclear. Since the...

Full description

Saved in:
Bibliographic Details
Published in:American journal of hypertension 2003-05, Vol.16 (S1), p.232A-232A
Main Authors: Zanchi, Anne, Perregaux, Christine, Maillard, Marc, Nussberger, Juerg, Brunner, Hans R., Burnier, Michel
Format: Article
Language:English
Subjects:
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Thiazolidinediones are high-affinity agonists of peroxisome proliferator-activated receptors (PPAR)-γ which have been found to lower blood pressure (BP) in animal models of diabetes and reno-vascular hypertension. The mechanisms leading to this decrease in blood pressure are still unclear. Since the renin-angiotensin system is a main regulator of blood pressure, we investigated the effects of pioglitazone on blood pressure, plasma renin activity and on the blood pressure response to exogenous angiotensin II in insulin-resistant Zucker rats. Pioglitazone 20mg/kg/d or vehicle were administered for 4 weeks to 8-weeks old fa/fa Zucker rats. Pioglitazone-treated rats were heavier than vehicle-treated rats (respectively 481g±8g vs 437±5g, p=0.0002, mean±SEM) and ate more (35.6±0.5g/d vs 28.9±0.3, p
ISSN:0895-7061
1941-7225
1879-1905
DOI:10.1016/S0895-7061(03)00710-6