P-593: Drug effects on aldosterone/plasma renin activity ratio in primary aldosteronism

We investigated the effect of atenolol, amlodipine, doxazosin, fosinopril, and irbesartan on the aldosterone/plasma renin activity ratio (ARR). ARR is routinely used as a screening test for primary aldosteronism, a common and specifically treatable form of secondary hypertension. Antihypertensive dr...

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Bibliographic Details
Published in:American journal of hypertension 2003-05, Vol.16 (S1), p.253A-253A
Main Authors: Mulatero, Paolo, Rabbia, Franco, Milan, Alberto, Morello, Fulvio, Leotta, Giannina, Colle, Sara Del, Caserta, Mimma, Tredici, Mirko, Veglio, Franco
Format: Article
Language:English
Subjects:
aldosterone renin ratio
antihypertensive treatment
primary aldosteronism
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Summary:We investigated the effect of atenolol, amlodipine, doxazosin, fosinopril, and irbesartan on the aldosterone/plasma renin activity ratio (ARR). ARR is routinely used as a screening test for primary aldosteronism, a common and specifically treatable form of secondary hypertension. Antihypertensive drugs can interfere with the interpretation of ARR, but a correct washout period can be potentially harmful. We measured ARR during single-drug therapy and after a 1-month washout period in a group of 230 patients with hypertension referred to our unit. The percent change of ARR in patients taking amlodipine was -17%±32; atenolol, 62%±82; doxazosin, -5%±26; fosinopril, -30%±24; and irbesartan, -43%±27. The ARR change induced by atenolol was significantly higher compared with that induced by all other drugs (P
ISSN:0895-7061
1941-7225
DOI:10.1016/S0895-7061(03)00766-0