P-297: Assesment of systemic vascular parameter and brachial artery function in hypertension

• Published in: American journal of hypertension 2001-04, Vol.14 (S1), p.128A-128A
• Main Authors: Delgado, Antonio J., Delgado-Almeida, Antonio R., Delgado-León, Carlos L.
• Format: Article
• Language: English
• Subjects: Arterial Distensibility; Brachial artery compliance; Vascular Compliance
• ISSN: 0895-7061; 1941-7225; 1879-1905
• DOI: 10.1016/S0895-7061(01)01468-6

RESULTS Although HT is currently identified by measurement of BP, there is growing medical consensus that endothelial function and vascular compliance are on the basis of its pathogenesis. To assess the significance of vascular parameters, non-invasive Arterial Waveform Analysis (Dyna Pulse 200) at rest, isometric hand grip & 15 min later, was recorded in 287 untreated HT subjects (Female n=150, Male n=137, age 53±14 yrs). SV Resistance (SVR), SV Compliance (SVC), Brachial Artery (BA) Resistance and Compliance, BA distensibility, BP, Pulse Pressure (PP) and HR were obtained basal and after 1 month follow-up. Correlations between BP levels and vascular parameters were evaluated.: a) Hypertensive subjects had basal BP of 144.6±28/ 79.5±13 mmHg; PP: 66±17 and HR 70±12 b/m; b) Vascular parameters were: SVR 1606±431 dy.s.cm5 and SVR index 2864±685 dy.s.cm5/m2; SVC 0.87±0.15 ml/mmHg and SVC index 0.51±0.08 ml/mmHg/m2; BAC 0.088±0.033 ml/mmHg and BA distensibility 4.21 ±0.89 %/mmHg. c) Linear Correlation: SBP was significantly correlated to SVC (r=-0.56, p.000), SVC index (r= -0.60, p .000), BAC (r=-0.61, p.000) and BAC index (r=-0.67, p.000), SVR (r=0.48, p.000), SVR index (r=0.50, p.000); while DBP and MBP showed good corelation with SVR (r=0.33, p.000), SVR index (r=0.47, p.000). CONCLUSION: Pathogenesis of HT involves significant alterations in SV and brachial artery function which have not been aparent from traditional BP evaluation.