P-294: Improved LV function, systemic vascular and brachial artery parameters in hypertension: The Venezuelan Telmisartan study

• Published in: American journal of hypertension 2001-04, Vol.14 (S1), p.127A-127A
• Main Authors: Delgado, Antonio J., Delgado-Almeida, Antonio R., Celis, Susana I., Delgado-León, Carlos L.
• Format: Article
• Language: English
• Subjects: Arterial compliance; Arterial waveform analysis; Telmisartan
• ISSN: 0895-7061; 1941-7225; 1879-1905
• DOI: 10.1016/S0895-7061(01)01465-0

Despite numerosus advances in pharmacology of HT, few therapeutic approach has been designed to assess drug effects on complex CV functions during measurement of BP. To assess such parameters, non-invasive Arterial Waveform Analysis (Dyna Pulse 200) at rest, isometric hand grip and 15 min later, was recorded in 31 HT subjects (Female n=18, Male n=13, age 54.1 ±9) on Telmisartan. LVET, dP/dT, LV contractility, LV Stroke Volume (LVSV), LV Stroke Work (LVSW), CO, Cadiac Work, SV Resistance and Compliance, Brachial Artery (BA) Compliance, BP, Pulse Pressure (PP) and HR were obtained basal and after 1 month of Telmisartan 40mgr. Paired T-test was perfomed, with statistical significance α=0.05. RESULTS: With Telmisartan: SBP (165±22 vs 132±15, p=0.00), DBP (90±14 vs 77±12, p=0.00) and PP (75±18 vs 55±12, p=0.00) were reduced, HR unchanged. dP/dTmax (1393±332 vs 1134±263, p=0.00), dP/dT 40 (35±8 vs 28±7, p=0.00), LVSW (90±19 vs 71±16, p=0.00) and Cardiac work (78±16 vs 63±13, p=0.00) were also reduced; while LVET, LVSV and CO unchanged. SVR (1783±277 vs 1524±275, p=0.00) was decreased; SV Compliance (1.16±0.3 vs 1.45±0.49, p=0.00) and BA Compliance (0.073±0.022 vs 0.097±0.032, p=0.00) increased at 1 month. CONCLUSION: This study provided the first integral evaluation of cardiac and vascular functions and BP on hypertensives receiving Telmisartan.