P-124: Fibrinolytic disturbances in hypertensive subjects with microalbuminuria

The aim of the study was to investigate the possible association between disturbances of the fibrinolytic system and microalbuminuria in subjects with essential hypertension We studied 104 individuals, 51 men and 53 women, aged 56.1±7.5 years, with essential hypertension diagnosed within the last si...

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Published in:American journal of hypertension 2001-04, Vol.14 (S1), p.70A-71A
Main Authors: Andreadis, E. A., Christopoulou- Kokkinou, V. D., Vassilopoulos, C. V., Stathopoulos, C. K., Giannakopoulos, N. S., Theodorides, T. G., Diamantopoulos, E. J.
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Language:English
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Arterial hypertension
Fibrinolysis
Microalbuminuria
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container_end_page 71A
container_issue S1
container_start_page 70A
container_title American journal of hypertension
container_volume 14
creator Andreadis, E. A.
Christopoulou- Kokkinou, V. D.
Vassilopoulos, C. V.
Stathopoulos, C. K.
Giannakopoulos, N. S.
Theodorides, T. G.
Diamantopoulos, E. J.
description The aim of the study was to investigate the possible association between disturbances of the fibrinolytic system and microalbuminuria in subjects with essential hypertension We studied 104 individuals, 51 men and 53 women, aged 56.1±7.5 years, with essential hypertension diagnosed within the last six months. They were not receiving any antihypertensive medication and they had no history of cardiovascular events. Individuals with known hypercoagulant disturbances, diabetes mellitus or impaired renal function as defined by serum creatinine levels higher than 1.3 mg/dl were excluded from the study. Office measurements of systolic and diastolic pressure were performed manually with a mercury sphygmomanometer. Urinary albumin excretion was measured by an immunoturbidimetric method (SERA-PAK immuno Microalbumin, Bayer). Subjects with urinary microalbuminuria between 30-300 mg/24hrs were considered as microalbuminuric. PAI-1 and t-PA serum concentrations were assayed with an ELISA method (STAGO). Serum levels of PAI-1 and t-PA were compared between the hypertensive subjects with and without microalbuminuria. Sixty-seven hypertensives had urine microalbumin levels
doi_str_mv 10.1016/S0895-7061(01)01674-0
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Office measurements of systolic and diastolic pressure were performed manually with a mercury sphygmomanometer. Urinary albumin excretion was measured by an immunoturbidimetric method (SERA-PAK immuno Microalbumin, Bayer). Subjects with urinary microalbuminuria between 30-300 mg/24hrs were considered as microalbuminuric. PAI-1 and t-PA serum concentrations were assayed with an ELISA method (STAGO). Serum levels of PAI-1 and t-PA were compared between the hypertensive subjects with and without microalbuminuria. Sixty-seven hypertensives had urine microalbumin levels &lt;30 mg/24hrs and 37 subjects between 30 and 300 mg/24hrs. When these two groups were analyzed according to their PAI-1 and t-PA serum levels it was found that the microalbuminuric patients had significantly higher PAI-1 comcentration than the non-microalbuminuric subjects (44.01±21.84 iu/ml vs 34.65±14.49 iu/ml, p=0.02). 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identifier ISSN: 0895-7061
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1941-7225
1879-1905
language eng
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source Oxford Journals Online
subjects Arterial hypertension
Fibrinolysis
Microalbuminuria
title P-124: Fibrinolytic disturbances in hypertensive subjects with microalbuminuria
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