P-317: Role of oxidative stress in the development of hypertension in SHR

To evaluate the potential role of the arterial oxidative stress in the pathogenesis of hypertension, the superoxide anion (O2.-) production in aortic ring and in cultured smooth muscle cells (SMC) from spontaneously hypertensive rats (SHR) was measured by lucigenin-enhanced chemiluminescence method....

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Bibliographic Details
Published in:American journal of hypertension 2001-04, Vol.14 (S1), p.134A-134A
Main Authors: Wu, Rong, Millette, Esther, Wu, Lingyun, de Champlain, Jacques
Format: Article
Language:English
Subjects:
NADH oxidase
spontaneously hypertensive rats
superoxide anion
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Summary:To evaluate the potential role of the arterial oxidative stress in the pathogenesis of hypertension, the superoxide anion (O2.-) production in aortic ring and in cultured smooth muscle cells (SMC) from spontaneously hypertensive rats (SHR) was measured by lucigenin-enhanced chemiluminescence method. The systolic blood pressure of 12-week old SHR was significantly higher than their controls WKY (p
ISSN:0895-7061
1941-7225
DOI:10.1016/S0895-7061(01)01731-9