P-155: Relationship between ACE-gene polymorphism and insulin resistance in never treated hypertensive patients

The association between angiotensin-converting enzyme (ACE)-gene polymorphism and insulin resistance (IR) in hypertensives remains controversial.Thus, we evaluated the possible association between IR and ACE-gene polymorphism in a group of hypertensive never treated patients in comparison with normo...

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Bibliographic Details
Published in:American journal of hypertension 2001-04, Vol.14 (S1), p.82A-82A
Main Authors: Ceravolo, Roberto, Iacopino, Saverio, Cloro, Cosima, Ventura, Giorgio, Maio, Raffaele, Gulletta, Elio, Perrotti, Nicola, Perticone, Francesco
Format: Article
Language:English
Subjects:
ACE-gene polymorphism
hypertension
Insulin resistance
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Summary:The association between angiotensin-converting enzyme (ACE)-gene polymorphism and insulin resistance (IR) in hypertensives remains controversial.Thus, we evaluated the possible association between IR and ACE-gene polymorphism in a group of hypertensive never treated patients in comparison with normotensive control group. We enrolled 200 (114M/86F; age = 45.5±4.7 years) hypertensive patients compared with 96 (54M/42F; age = 44.0±4.7 years) normotensive subjects. Using a double PCR assay identified ACE genotypes. We determined fasting glucose and insulin by using the glucose oxidase method and standard radioimmunoassay technique. IR was estimated by using the homeostasis model assessment (HOMAIR). Both fasting glucose (5.0±0.3 mmol/L vs 4.7±0.3 mmol/L; p
ISSN:0895-7061
1941-7225
1879-1905
DOI:10.1016/S0895-7061(01)01764-2