P-472: Fat impairs stress-induced pressure natriuresis in African-American boys

We hypothesize that impaired stress-induced pressure natriuresis is a pathophysiologic mechanism underlying obesity-associated hypertension in African-Americans. In this study 55 African-American boys and 71 girls aged 15–18 years underwent a 5-hour stress protocol (2 hour baseline, 1 hour stress, 2...

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Published in:American journal of hypertension 2003-05, Vol.16 (S1), p.209A-210A
Main Authors: Harshfield, Gregory A., Wilson, Martha E., McLeod, Kathryn, Hanevold, Coral, Kapuku, Gaston, Mackey, Lynne, Gillis, Deloris, Edmunds, Lesley
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Language:English
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Gender Differences
Obesity
Stress
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container_issue S1
container_start_page 209A
container_title American journal of hypertension
container_volume 16
creator Harshfield, Gregory A.
Wilson, Martha E.
McLeod, Kathryn
Hanevold, Coral
Kapuku, Gaston
Mackey, Lynne
Gillis, Deloris
Edmunds, Lesley
description We hypothesize that impaired stress-induced pressure natriuresis is a pathophysiologic mechanism underlying obesity-associated hypertension in African-Americans. In this study 55 African-American boys and 71 girls aged 15–18 years underwent a 5-hour stress protocol (2 hour baseline, 1 hour stress, 2 hour recovery) after being brought into similar levels of sodium balance. Dual-energy x-ray absorptiometry was performed to determine total percent body fat. Both girls and boys showed significant increases from baseline to stress and significant decreases from stress to recovery for blood pressure and sodium excretion (P
doi_str_mv 10.1016/S0895-7061(03)00644-7
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Body fat was also negatively related to the post-stress decline in blood pressure (r=−0.24; P<0.04) which was positively correlated with the stress-induced change in angiotensin II. In contrast, body fat was not correlated with sodium handling, blood pressure, or angiotensin II in girls. These results may help to explain how the interactions between salt, stress, and obesity contribute to the increased incidence and prevalence of HTN in African-American males. 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In this study 55 African-American boys and 71 girls aged 15–18 years underwent a 5-hour stress protocol (2 hour baseline, 1 hour stress, 2 hour recovery) after being brought into similar levels of sodium balance. Dual-energy x-ray absorptiometry was performed to determine total percent body fat. Both girls and boys showed significant increases from baseline to stress and significant decreases from stress to recovery for blood pressure and sodium excretion (P<0.01 for all), with greater changes for boys (P<0.01 for all). For girls, blood pressure during stress was related to urinary sodium excretion (r=0.31; P<0.005) but not for boys. For boys, body fat was negatively correlated with the change in sodium excretion from baseline to stress (r=−0.37; P<0.006) and sodium excretion during stress (r=−0.28; P<0.04), which in turn was related to angiotensin II (r=−0.41; P<0.41). 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subjects Gender Differences
Obesity
Stress
title P-472: Fat impairs stress-induced pressure natriuresis in African-American boys
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