Drug Particle Delivery Investigation Through a Valveless Micropump

Micropumps with various types of actuations are being used in microfluidic transport for liquid drug delivery. Due to the complexity of the flow field, particle transport through a valveless micropump might be challenging in comparison to a pressure-driven flow micropumps. In order to better underst...

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Bibliographic Details
Published in:Journal of microelectromechanical systems 2010-12, Vol.19 (6), p.1390-1399
Main Authors: Guoguang Su, Pidaparti, R M
Format: Article
Language:English
Subjects:
Actuation
Actuators
Applied fluid mechanics
Applied sciences
Biological and medical sciences
Computation
Computational modeling
computations
Computer simulation
Design engineering
Drug delivery
Drugs
Exact sciences and technology
Fluid dynamics
Fluidics
Fundamental areas of phenomenology (including applications)
General pharmacology
Instruments, apparatus, components and techniques common to several branches of physics and astronomy
Mechanical engineering. Machine design
Mechanical instruments, equipment and techniques
Medical sciences
Microfluidics
Micromechanical devices and systems
Micropumps
particles
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physics
Precision engineering, watch making
Simulation
Transport
Transporting
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Summary:Micropumps with various types of actuations are being used in microfluidic transport for liquid drug delivery. Due to the complexity of the flow field, particle transport through a valveless micropump might be challenging in comparison to a pressure-driven flow micropumps. In order to better understand and develop an optimized design for the delivery of drug particles through valveless micropumps, computational simulations may be necessary. In this paper, the transport of drug particles through the valveless micropump is simulated through 3-D computational fluid dynamics combined with discrete particle transport methods. After computational validation, the effects of actuation frequency, particle size, and transporting style on the particle transport are investigated. Both the actuation frequency and transporting pattern have a strong relationship in terms of resident times and the spatial distribution of the transported particles through the designed micropump. The computational analysis results presented demonstrate that it is possible to optimize the proposed valveless micropump design through numerical simulations for specific delivery of drug particles.
ISSN:1057-7157
1941-0158
DOI:10.1109/JMEMS.2010.2082502