Loading…
Gastrointestinal and liver side effects of drugs in elderly patients
It is expected that the percentage of people >60 years of age will be 22% worldwide by the year 2050. Multi-morbidity and poly-pharmacy are common in individuals during old age, while adverse drug reactions are at least twice as common in the elderly compared to younger adults. Publications relat...
Saved in:
| Published in: | Baillière's best practice & research. Clinical gastroenterology 2010-04, Vol.24 (2), p.203-215 |
|---|---|
| Main Authors: | , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c526t-34c08d009eee369ccf84a98443fe184cb29399229accb3a837da85be87ed38c33 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c526t-34c08d009eee369ccf84a98443fe184cb29399229accb3a837da85be87ed38c33 |
| container_end_page | 215 |
| container_issue | 2 |
| container_start_page | 203 |
| container_title | Baillière's best practice & research. Clinical gastroenterology |
| container_volume | 24 |
| creator | Triantafyllou, Konstantinos, MD, PhD Vlachogiannakos, Jiannis, MD, PhD Ladas, Spiros D., MD, PhD |
| description | It is expected that the percentage of people >60 years of age will be 22% worldwide by the year 2050. Multi-morbidity and poly-pharmacy are common in individuals during old age, while adverse drug reactions are at least twice as common in the elderly compared to younger adults. Publications related to drug side effects are rather rare in this age group since most clinical trials exclude patients >75–80 years of age. Gastrointestinal adverse drug reactions studied in the elderly include non-steroidal anti-inflammatory drugs (NSAIDs) and anticoagulant-induced gastrointestinal tract mucosal injuries. Malabsorption, diarrhoea and constipation are common side effects of laxatives, antibiotics, anticholinergics and calcium channel blockers. Drug (amoxycilin/clavulanic acid, isoniazide, nitrofurantoin, diclifenac and methotrexate)-induced hepatotoxicity in the elderly is four times more common than in younger adults and may simulate almost all known liver disorders. Further clinical studies are needed to investigate gastrointestinal and hepatic side effects of drugs in elderly patients. |
| doi_str_mv | 10.1016/j.bpg.2010.02.004 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_journals_1032597593</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1521691810000181</els_id><sourcerecordid>2730546891</sourcerecordid><originalsourceid>FETCH-LOGICAL-c526t-34c08d009eee369ccf84a98443fe184cb29399229accb3a837da85be87ed38c33</originalsourceid><addsrcrecordid>eNp9kUtLAzEUhYMoVqs_wI0EXM-YxzwSBEGqVqHgQl2HTHKnpE5najIt9N-boVXBhavcwDmXe76D0AUlKSW0uF6k1WqeMhL_hKWEZAfohOacJVTS4nCYGU0KScUInYawICSapDxGI0YYKwnnJ-h-qkPvO9f2EHrX6gbr1uLGbcDj4CxgqGswfcBdja1fzwN2LYbGgm-2eKV7B20fztBRrZsA5_t3jN4fH94mT8nsZfo8uZslJmdFn_DMEGEJkQDAC2lMLTItRZbxGqjITMUkl5IxqY2puBa8tFrkFYgSLBeG8zG62u1d-e5zHQ9Wi27t49FBUcJZLstcDiq6UxnfheChVivvltpvo0gN3NRCRW5q4KYIU5Fb9FzuN6-rJdgfxzeoKLjZCSDm2zjwKpiY3YB1PvJRtnP_rr_94zaNa53RzQdsIfymUCEa1OtQ3NAbJUNngvIvxUiRyg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1032597593</pqid></control><display><type>article</type><title>Gastrointestinal and liver side effects of drugs in elderly patients</title><source>ScienceDirect Journals</source><creator>Triantafyllou, Konstantinos, MD, PhD ; Vlachogiannakos, Jiannis, MD, PhD ; Ladas, Spiros D., MD, PhD</creator><creatorcontrib>Triantafyllou, Konstantinos, MD, PhD ; Vlachogiannakos, Jiannis, MD, PhD ; Ladas, Spiros D., MD, PhD</creatorcontrib><description>It is expected that the percentage of people >60 years of age will be 22% worldwide by the year 2050. Multi-morbidity and poly-pharmacy are common in individuals during old age, while adverse drug reactions are at least twice as common in the elderly compared to younger adults. Publications related to drug side effects are rather rare in this age group since most clinical trials exclude patients >75–80 years of age. Gastrointestinal adverse drug reactions studied in the elderly include non-steroidal anti-inflammatory drugs (NSAIDs) and anticoagulant-induced gastrointestinal tract mucosal injuries. Malabsorption, diarrhoea and constipation are common side effects of laxatives, antibiotics, anticholinergics and calcium channel blockers. Drug (amoxycilin/clavulanic acid, isoniazide, nitrofurantoin, diclifenac and methotrexate)-induced hepatotoxicity in the elderly is four times more common than in younger adults and may simulate almost all known liver disorders. Further clinical studies are needed to investigate gastrointestinal and hepatic side effects of drugs in elderly patients.</description><identifier>ISSN: 1521-6918</identifier><identifier>EISSN: 1532-1916</identifier><identifier>DOI: 10.1016/j.bpg.2010.02.004</identifier><identifier>PMID: 20227033</identifier><identifier>CODEN: BPRCB6</identifier><language>eng</language><publisher>Netherlands: Elsevier Ltd</publisher><subject>Age Factors ; Aged ; Aged, 80 and over ; Amoxicillin/clavulanic acid ; Cancer ; Chemical and Drug Induced Liver Injury - etiology ; Drug therapy ; Drug-induced constipation ; Drug-induced diarrhoea ; Drug-induced gastrointestinal lesions ; Drug-induced liver injury ; Drug-Related Side Effects and Adverse Reactions ; Elderly ; Gastroenterology and Hepatology ; Gastrointestinal Diseases - chemically induced ; Gastrointestinal Tract - drug effects ; Hepatotoxicity ; Humans ; Isoniazid ; Liver ; Liver - drug effects ; Mortality ; Older people ; Pill oesophagitis ; Risk Assessment ; Risk Factors</subject><ispartof>Baillière's best practice & research. Clinical gastroenterology, 2010-04, Vol.24 (2), p.203-215</ispartof><rights>Elsevier Ltd</rights><rights>2010 Elsevier Ltd</rights><rights>Copyright 2010 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c526t-34c08d009eee369ccf84a98443fe184cb29399229accb3a837da85be87ed38c33</citedby><cites>FETCH-LOGICAL-c526t-34c08d009eee369ccf84a98443fe184cb29399229accb3a837da85be87ed38c33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20227033$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Triantafyllou, Konstantinos, MD, PhD</creatorcontrib><creatorcontrib>Vlachogiannakos, Jiannis, MD, PhD</creatorcontrib><creatorcontrib>Ladas, Spiros D., MD, PhD</creatorcontrib><title>Gastrointestinal and liver side effects of drugs in elderly patients</title><title>Baillière's best practice & research. Clinical gastroenterology</title><addtitle>Best Pract Res Clin Gastroenterol</addtitle><description>It is expected that the percentage of people >60 years of age will be 22% worldwide by the year 2050. Multi-morbidity and poly-pharmacy are common in individuals during old age, while adverse drug reactions are at least twice as common in the elderly compared to younger adults. Publications related to drug side effects are rather rare in this age group since most clinical trials exclude patients >75–80 years of age. Gastrointestinal adverse drug reactions studied in the elderly include non-steroidal anti-inflammatory drugs (NSAIDs) and anticoagulant-induced gastrointestinal tract mucosal injuries. Malabsorption, diarrhoea and constipation are common side effects of laxatives, antibiotics, anticholinergics and calcium channel blockers. Drug (amoxycilin/clavulanic acid, isoniazide, nitrofurantoin, diclifenac and methotrexate)-induced hepatotoxicity in the elderly is four times more common than in younger adults and may simulate almost all known liver disorders. Further clinical studies are needed to investigate gastrointestinal and hepatic side effects of drugs in elderly patients.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Amoxicillin/clavulanic acid</subject><subject>Cancer</subject><subject>Chemical and Drug Induced Liver Injury - etiology</subject><subject>Drug therapy</subject><subject>Drug-induced constipation</subject><subject>Drug-induced diarrhoea</subject><subject>Drug-induced gastrointestinal lesions</subject><subject>Drug-induced liver injury</subject><subject>Drug-Related Side Effects and Adverse Reactions</subject><subject>Elderly</subject><subject>Gastroenterology and Hepatology</subject><subject>Gastrointestinal Diseases - chemically induced</subject><subject>Gastrointestinal Tract - drug effects</subject><subject>Hepatotoxicity</subject><subject>Humans</subject><subject>Isoniazid</subject><subject>Liver</subject><subject>Liver - drug effects</subject><subject>Mortality</subject><subject>Older people</subject><subject>Pill oesophagitis</subject><subject>Risk Assessment</subject><subject>Risk Factors</subject><issn>1521-6918</issn><issn>1532-1916</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2010</creationdate><recordtype>article</recordtype><recordid>eNp9kUtLAzEUhYMoVqs_wI0EXM-YxzwSBEGqVqHgQl2HTHKnpE5najIt9N-boVXBhavcwDmXe76D0AUlKSW0uF6k1WqeMhL_hKWEZAfohOacJVTS4nCYGU0KScUInYawICSapDxGI0YYKwnnJ-h-qkPvO9f2EHrX6gbr1uLGbcDj4CxgqGswfcBdja1fzwN2LYbGgm-2eKV7B20fztBRrZsA5_t3jN4fH94mT8nsZfo8uZslJmdFn_DMEGEJkQDAC2lMLTItRZbxGqjITMUkl5IxqY2puBa8tFrkFYgSLBeG8zG62u1d-e5zHQ9Wi27t49FBUcJZLstcDiq6UxnfheChVivvltpvo0gN3NRCRW5q4KYIU5Fb9FzuN6-rJdgfxzeoKLjZCSDm2zjwKpiY3YB1PvJRtnP_rr_94zaNa53RzQdsIfymUCEa1OtQ3NAbJUNngvIvxUiRyg</recordid><startdate>20100401</startdate><enddate>20100401</enddate><creator>Triantafyllou, Konstantinos, MD, PhD</creator><creator>Vlachogiannakos, Jiannis, MD, PhD</creator><creator>Ladas, Spiros D., MD, PhD</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>NAPCQ</scope></search><sort><creationdate>20100401</creationdate><title>Gastrointestinal and liver side effects of drugs in elderly patients</title><author>Triantafyllou, Konstantinos, MD, PhD ; Vlachogiannakos, Jiannis, MD, PhD ; Ladas, Spiros D., MD, PhD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c526t-34c08d009eee369ccf84a98443fe184cb29399229accb3a837da85be87ed38c33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2010</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Amoxicillin/clavulanic acid</topic><topic>Cancer</topic><topic>Chemical and Drug Induced Liver Injury - etiology</topic><topic>Drug therapy</topic><topic>Drug-induced constipation</topic><topic>Drug-induced diarrhoea</topic><topic>Drug-induced gastrointestinal lesions</topic><topic>Drug-induced liver injury</topic><topic>Drug-Related Side Effects and Adverse Reactions</topic><topic>Elderly</topic><topic>Gastroenterology and Hepatology</topic><topic>Gastrointestinal Diseases - chemically induced</topic><topic>Gastrointestinal Tract - drug effects</topic><topic>Hepatotoxicity</topic><topic>Humans</topic><topic>Isoniazid</topic><topic>Liver</topic><topic>Liver - drug effects</topic><topic>Mortality</topic><topic>Older people</topic><topic>Pill oesophagitis</topic><topic>Risk Assessment</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Triantafyllou, Konstantinos, MD, PhD</creatorcontrib><creatorcontrib>Vlachogiannakos, Jiannis, MD, PhD</creatorcontrib><creatorcontrib>Ladas, Spiros D., MD, PhD</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><jtitle>Baillière's best practice & research. Clinical gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Triantafyllou, Konstantinos, MD, PhD</au><au>Vlachogiannakos, Jiannis, MD, PhD</au><au>Ladas, Spiros D., MD, PhD</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gastrointestinal and liver side effects of drugs in elderly patients</atitle><jtitle>Baillière's best practice & research. Clinical gastroenterology</jtitle><addtitle>Best Pract Res Clin Gastroenterol</addtitle><date>2010-04-01</date><risdate>2010</risdate><volume>24</volume><issue>2</issue><spage>203</spage><epage>215</epage><pages>203-215</pages><issn>1521-6918</issn><eissn>1532-1916</eissn><coden>BPRCB6</coden><abstract>It is expected that the percentage of people >60 years of age will be 22% worldwide by the year 2050. Multi-morbidity and poly-pharmacy are common in individuals during old age, while adverse drug reactions are at least twice as common in the elderly compared to younger adults. Publications related to drug side effects are rather rare in this age group since most clinical trials exclude patients >75–80 years of age. Gastrointestinal adverse drug reactions studied in the elderly include non-steroidal anti-inflammatory drugs (NSAIDs) and anticoagulant-induced gastrointestinal tract mucosal injuries. Malabsorption, diarrhoea and constipation are common side effects of laxatives, antibiotics, anticholinergics and calcium channel blockers. Drug (amoxycilin/clavulanic acid, isoniazide, nitrofurantoin, diclifenac and methotrexate)-induced hepatotoxicity in the elderly is four times more common than in younger adults and may simulate almost all known liver disorders. Further clinical studies are needed to investigate gastrointestinal and hepatic side effects of drugs in elderly patients.</abstract><cop>Netherlands</cop><pub>Elsevier Ltd</pub><pmid>20227033</pmid><doi>10.1016/j.bpg.2010.02.004</doi><tpages>13</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1521-6918 |
| ispartof | Baillière's best practice & research. Clinical gastroenterology, 2010-04, Vol.24 (2), p.203-215 |
| issn | 1521-6918 1532-1916 |
| language | eng |
| recordid | cdi_proquest_journals_1032597593 |
| source | ScienceDirect Journals |
| subjects | Age Factors Aged Aged, 80 and over Amoxicillin/clavulanic acid Cancer Chemical and Drug Induced Liver Injury - etiology Drug therapy Drug-induced constipation Drug-induced diarrhoea Drug-induced gastrointestinal lesions Drug-induced liver injury Drug-Related Side Effects and Adverse Reactions Elderly Gastroenterology and Hepatology Gastrointestinal Diseases - chemically induced Gastrointestinal Tract - drug effects Hepatotoxicity Humans Isoniazid Liver Liver - drug effects Mortality Older people Pill oesophagitis Risk Assessment Risk Factors |
| title | Gastrointestinal and liver side effects of drugs in elderly patients |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T06%3A58%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Gastrointestinal%20and%20liver%20side%20effects%20of%20drugs%20in%20elderly%20patients&rft.jtitle=Bailli%C3%A8re's%20best%20practice%20&%20research.%20Clinical%20gastroenterology&rft.au=Triantafyllou,%20Konstantinos,%20MD,%20PhD&rft.date=2010-04-01&rft.volume=24&rft.issue=2&rft.spage=203&rft.epage=215&rft.pages=203-215&rft.issn=1521-6918&rft.eissn=1532-1916&rft.coden=BPRCB6&rft_id=info:doi/10.1016/j.bpg.2010.02.004&rft_dat=%3Cproquest_cross%3E2730546891%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c526t-34c08d009eee369ccf84a98443fe184cb29399229accb3a837da85be87ed38c33%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1032597593&rft_id=info:pmid/20227033&rfr_iscdi=true |