sup 18^F-FDG uptake by spleen helps rapidly predict the dose level after total body irradiation in a Tibetan minipig model

To investigate whether ^sup 18^F- FDG uptake can be applied in dosimetry to facilitate the rapid and accurate evaluation of individual radiation doses after a nuclear accident. Forty-eight Tibetan minipigs were randomised into a control group (n=3) and treatment groups (n=45). ^sup 18^F-FDG combined...

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Bibliographic Details
Published in:European radiology 2012-09, Vol.22 (9), p.1844
Main Authors: Wang, Yu Jue, Wu, Shao Jie, Guo, Kun Yuan, Chen, Chi, Xie, Qiang, Gu, Wei Wang, Cai, Liang, Zou, Fei
Format: Article
Language:English
Subjects:
Apoptosis
Dosimetry
Glucose
Laboratory animals
Lymphocytes
Mass casualty incidents
Nuclear accidents & safety
Radiation
Spleen
Tomography
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Summary:To investigate whether ^sup 18^F- FDG uptake can be applied in dosimetry to facilitate the rapid and accurate evaluation of individual radiation doses after a nuclear accident. Forty-eight Tibetan minipigs were randomised into a control group (n=3) and treatment groups (n=45). ^sup 18^F-FDG combined positron-emission tomography and computed tomography (PET/CT) were carried out before total body irradiation (TBI) and at 6, 24 and 72 h after receiving TBI doses ranging from 1 to 11 Gy. Spleen tissues and blood samples were also collected for histological examination, apoptosis and blood analysis. Mean standardised uptake values (SUVs) of the spleen showed significant differences between the experimental and the control groups. Spleen SUV at 6 h post-irradiation showed significant correlation with radiation dose; Spearman's correlation coefficient was 0.97 (P
ISSN:0938-7994
1432-1084
DOI:10.1007/s00330-012-2451-0