PNU-120596, a positive allosteric modulator of [alpha]7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats

The α7 nicotinic acetylcholine receptors (nAChRs) have been highlighted as a target for cognitive enhancement in schizophrenia. Adult female hooded Lister rats received sub-chronic phencyclidine (PCP) (2 mg/kg) or vehicle i.p. twice daily for 7 days, followed by 7 days' washout. PCP-treated rat...

Full description

Saved in:
Bibliographic Details
Published in:Journal of psychopharmacology (Oxford) 2012-09, Vol.26 (9), p.1265
Main Authors: McLean, Samantha L, Idris, Nagi F, Grayson, Ben, Gendle, David F, Mackie, Claire, Lesage, Anne S, Pemberton, Darrel J, Neill, Jo C
Format: Article
Language:English
Subjects:
Animal cognition
Rodents
Schizophrenia
Visual task performance
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page
container_issue 9
container_start_page 1265
container_title Journal of psychopharmacology (Oxford)
container_volume 26
creator McLean, Samantha L
Idris, Nagi F
Grayson, Ben
Gendle, David F
Mackie, Claire
Lesage, Anne S
Pemberton, Darrel J
Neill, Jo C
description The α7 nicotinic acetylcholine receptors (nAChRs) have been highlighted as a target for cognitive enhancement in schizophrenia. Adult female hooded Lister rats received sub-chronic phencyclidine (PCP) (2 mg/kg) or vehicle i.p. twice daily for 7 days, followed by 7 days' washout. PCP-treated rats then received PNU-120596 (10 mg/kg; s.c.) or saline and were tested in the attentional set-shifting task. Sub-chronic PCP produced a significant cognitive deficit in the extra-dimensional shift (EDS) phase of the task (p < 0.001, compared with vehicle). PNU-120596 significantly improved performance of PCP-treated rats in the EDS phase of the attentional set-shifting task (p < 0.001). In conclusion, these data demonstrate that PNU-120596 improves cognitive dysfunction in our animal model of cognitive dysfunction in schizophrenia, most likely via modulation of α7 nACh receptors. [PUBLICATION ABSTRACT]
format article
fullrecord <record><control><sourceid>proquest</sourceid><recordid>TN_cdi_proquest_journals_1032647314</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2731030171</sourcerecordid><originalsourceid>FETCH-proquest_journals_10326473143</originalsourceid><addsrcrecordid>eNqNjstKA0EQRQdRMD7-ocBtGqbnnbUorsSFWYmEtqcmU7HTPXbVBPKR_pMd9APc1L2Lwz11li101WjVFl19ni3yolmprtP6Mrti3uW5bqqmXmTfL89rpYu8XjVLMDAFJqEDgnEusGAkC_vQz85IiBAGeDNuGs17C55sEEoXjEU5OjsGRx4hosUpwbxM9YCRkdMuzx_KjjGc-GlEb4_WUZ94Rb6fLfZgw9b_qnscyJIAeZAxfSKCXih444BRFI80JPEWxPDnCRpwb1wSG-Gb7GIwjvH2L6-zu8eH1_snNcXwNSPLZhfmmJZ4o_OyaKq21FX5P-oH8C5ufw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1032647314</pqid></control><display><type>article</type><title>PNU-120596, a positive allosteric modulator of [alpha]7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats</title><source>SAGE:Jisc Collections:SAGE Journals Read and Publish 2023-2024:2025 extension (reading list)</source><creator>McLean, Samantha L ; Idris, Nagi F ; Grayson, Ben ; Gendle, David F ; Mackie, Claire ; Lesage, Anne S ; Pemberton, Darrel J ; Neill, Jo C</creator><creatorcontrib>McLean, Samantha L ; Idris, Nagi F ; Grayson, Ben ; Gendle, David F ; Mackie, Claire ; Lesage, Anne S ; Pemberton, Darrel J ; Neill, Jo C</creatorcontrib><description>The α7 nicotinic acetylcholine receptors (nAChRs) have been highlighted as a target for cognitive enhancement in schizophrenia. Adult female hooded Lister rats received sub-chronic phencyclidine (PCP) (2 mg/kg) or vehicle i.p. twice daily for 7 days, followed by 7 days' washout. PCP-treated rats then received PNU-120596 (10 mg/kg; s.c.) or saline and were tested in the attentional set-shifting task. Sub-chronic PCP produced a significant cognitive deficit in the extra-dimensional shift (EDS) phase of the task (p &lt; 0.001, compared with vehicle). PNU-120596 significantly improved performance of PCP-treated rats in the EDS phase of the attentional set-shifting task (p &lt; 0.001). In conclusion, these data demonstrate that PNU-120596 improves cognitive dysfunction in our animal model of cognitive dysfunction in schizophrenia, most likely via modulation of α7 nACh receptors. [PUBLICATION ABSTRACT]</description><identifier>ISSN: 0269-8811</identifier><identifier>EISSN: 1461-7285</identifier><identifier>CODEN: JOPSEQ</identifier><language>eng</language><publisher>London: Sage Publications Ltd</publisher><subject>Animal cognition ; Rodents ; Schizophrenia ; Visual task performance</subject><ispartof>Journal of psychopharmacology (Oxford), 2012-09, Vol.26 (9), p.1265</ispartof><rights>Copyright Sage Publications Ltd. Sep 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids></links><search><creatorcontrib>McLean, Samantha L</creatorcontrib><creatorcontrib>Idris, Nagi F</creatorcontrib><creatorcontrib>Grayson, Ben</creatorcontrib><creatorcontrib>Gendle, David F</creatorcontrib><creatorcontrib>Mackie, Claire</creatorcontrib><creatorcontrib>Lesage, Anne S</creatorcontrib><creatorcontrib>Pemberton, Darrel J</creatorcontrib><creatorcontrib>Neill, Jo C</creatorcontrib><title>PNU-120596, a positive allosteric modulator of [alpha]7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats</title><title>Journal of psychopharmacology (Oxford)</title><description>The α7 nicotinic acetylcholine receptors (nAChRs) have been highlighted as a target for cognitive enhancement in schizophrenia. Adult female hooded Lister rats received sub-chronic phencyclidine (PCP) (2 mg/kg) or vehicle i.p. twice daily for 7 days, followed by 7 days' washout. PCP-treated rats then received PNU-120596 (10 mg/kg; s.c.) or saline and were tested in the attentional set-shifting task. Sub-chronic PCP produced a significant cognitive deficit in the extra-dimensional shift (EDS) phase of the task (p &lt; 0.001, compared with vehicle). PNU-120596 significantly improved performance of PCP-treated rats in the EDS phase of the attentional set-shifting task (p &lt; 0.001). In conclusion, these data demonstrate that PNU-120596 improves cognitive dysfunction in our animal model of cognitive dysfunction in schizophrenia, most likely via modulation of α7 nACh receptors. [PUBLICATION ABSTRACT]</description><subject>Animal cognition</subject><subject>Rodents</subject><subject>Schizophrenia</subject><subject>Visual task performance</subject><issn>0269-8811</issn><issn>1461-7285</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><recordid>eNqNjstKA0EQRQdRMD7-ocBtGqbnnbUorsSFWYmEtqcmU7HTPXbVBPKR_pMd9APc1L2Lwz11li101WjVFl19ni3yolmprtP6Mrti3uW5bqqmXmTfL89rpYu8XjVLMDAFJqEDgnEusGAkC_vQz85IiBAGeDNuGs17C55sEEoXjEU5OjsGRx4hosUpwbxM9YCRkdMuzx_KjjGc-GlEb4_WUZ94Rb6fLfZgw9b_qnscyJIAeZAxfSKCXih444BRFI80JPEWxPDnCRpwb1wSG-Gb7GIwjvH2L6-zu8eH1_snNcXwNSPLZhfmmJZ4o_OyaKq21FX5P-oH8C5ufw</recordid><startdate>20120901</startdate><enddate>20120901</enddate><creator>McLean, Samantha L</creator><creator>Idris, Nagi F</creator><creator>Grayson, Ben</creator><creator>Gendle, David F</creator><creator>Mackie, Claire</creator><creator>Lesage, Anne S</creator><creator>Pemberton, Darrel J</creator><creator>Neill, Jo C</creator><general>Sage Publications Ltd</general><scope>7TK</scope></search><sort><creationdate>20120901</creationdate><title>PNU-120596, a positive allosteric modulator of [alpha]7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats</title><author>McLean, Samantha L ; Idris, Nagi F ; Grayson, Ben ; Gendle, David F ; Mackie, Claire ; Lesage, Anne S ; Pemberton, Darrel J ; Neill, Jo C</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-proquest_journals_10326473143</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animal cognition</topic><topic>Rodents</topic><topic>Schizophrenia</topic><topic>Visual task performance</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>McLean, Samantha L</creatorcontrib><creatorcontrib>Idris, Nagi F</creatorcontrib><creatorcontrib>Grayson, Ben</creatorcontrib><creatorcontrib>Gendle, David F</creatorcontrib><creatorcontrib>Mackie, Claire</creatorcontrib><creatorcontrib>Lesage, Anne S</creatorcontrib><creatorcontrib>Pemberton, Darrel J</creatorcontrib><creatorcontrib>Neill, Jo C</creatorcontrib><collection>Neurosciences Abstracts</collection><jtitle>Journal of psychopharmacology (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>McLean, Samantha L</au><au>Idris, Nagi F</au><au>Grayson, Ben</au><au>Gendle, David F</au><au>Mackie, Claire</au><au>Lesage, Anne S</au><au>Pemberton, Darrel J</au><au>Neill, Jo C</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>PNU-120596, a positive allosteric modulator of [alpha]7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats</atitle><jtitle>Journal of psychopharmacology (Oxford)</jtitle><date>2012-09-01</date><risdate>2012</risdate><volume>26</volume><issue>9</issue><spage>1265</spage><pages>1265-</pages><issn>0269-8811</issn><eissn>1461-7285</eissn><coden>JOPSEQ</coden><abstract>The α7 nicotinic acetylcholine receptors (nAChRs) have been highlighted as a target for cognitive enhancement in schizophrenia. Adult female hooded Lister rats received sub-chronic phencyclidine (PCP) (2 mg/kg) or vehicle i.p. twice daily for 7 days, followed by 7 days' washout. PCP-treated rats then received PNU-120596 (10 mg/kg; s.c.) or saline and were tested in the attentional set-shifting task. Sub-chronic PCP produced a significant cognitive deficit in the extra-dimensional shift (EDS) phase of the task (p &lt; 0.001, compared with vehicle). PNU-120596 significantly improved performance of PCP-treated rats in the EDS phase of the attentional set-shifting task (p &lt; 0.001). In conclusion, these data demonstrate that PNU-120596 improves cognitive dysfunction in our animal model of cognitive dysfunction in schizophrenia, most likely via modulation of α7 nACh receptors. [PUBLICATION ABSTRACT]</abstract><cop>London</cop><pub>Sage Publications Ltd</pub></addata></record>
fulltext fulltext
identifier ISSN: 0269-8811
ispartof Journal of psychopharmacology (Oxford), 2012-09, Vol.26 (9), p.1265
issn 0269-8811
1461-7285
language eng
recordid cdi_proquest_journals_1032647314
source SAGE:Jisc Collections:SAGE Journals Read and Publish 2023-2024:2025 extension (reading list)
subjects Animal cognition
Rodents
Schizophrenia
Visual task performance
title PNU-120596, a positive allosteric modulator of [alpha]7 nicotinic acetylcholine receptors, reverses a sub-chronic phencyclidine-induced cognitive deficit in the attentional set-shifting task in female rats
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-27T00%3A40%3A04IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=PNU-120596,%20a%20positive%20allosteric%20modulator%20of%20%5Balpha%5D7%20nicotinic%20acetylcholine%20receptors,%20reverses%20a%20sub-chronic%20phencyclidine-induced%20cognitive%20deficit%20in%20the%20attentional%20set-shifting%20task%20in%20female%20rats&rft.jtitle=Journal%20of%20psychopharmacology%20(Oxford)&rft.au=McLean,%20Samantha%20L&rft.date=2012-09-01&rft.volume=26&rft.issue=9&rft.spage=1265&rft.pages=1265-&rft.issn=0269-8811&rft.eissn=1461-7285&rft.coden=JOPSEQ&rft_id=info:doi/&rft_dat=%3Cproquest%3E2731030171%3C/proquest%3E%3Cgrp_id%3Ecdi_FETCH-proquest_journals_10326473143%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1032647314&rft_id=info:pmid/&rfr_iscdi=true