Gastrointestinal medications in pregnancy

Management of the pregnant patient presents unique challenges to the treating physician. Current Food and Drug Administration classifications do not necessarily reflect clinical experience or recent literature. Ideally, one should use the lowest-risk drug possible, with attention to the appropriate...

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Bibliographic Details
Published in:Baillière's best practice & research. Clinical gastroenterology 2007-01, Vol.21 (5), p.849-877
Main Author: Mahadevan, Uma, MD
Format: Article
Language:English
Subjects:
Adjuvants, Anesthesia - therapeutic use
Anesthesia
Anti-Bacterial Agents - therapeutic use
Antiemetics - therapeutic use
Babies
Drug dosages
Drug therapy
endoscopy
Endoscopy, Digestive System
Female
Gastroenterology and Hepatology
gastrointestinal
Gastrointestinal Agents - therapeutic use
Gastrointestinal Diseases - diagnosis
Gastrointestinal Diseases - drug therapy
Humans
irritable bowel syndrome
Liver Diseases - drug therapy
Medicaid
medications
Milk
Mothers
Pregnancy
Pregnancy Complications - diagnosis
Pregnancy Complications - drug therapy
Proton Pump Inhibitors - therapeutic use
Womens health
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Summary:Management of the pregnant patient presents unique challenges to the treating physician. Current Food and Drug Administration classifications do not necessarily reflect clinical experience or recent literature. Ideally, one should use the lowest-risk drug possible, with attention to the appropriate level of efficacy for the patient's condition, the stage of pregnancy and dose adjustment. Every treatment decision should be fully discussed with the patient and a multidisciplinary team that should include the obstetrician and, if appropriate, the paediatrician. This review will cover the medications commonly used to treat gastrointestinal disease. The majority of medications can be categorised as ‘low risk’ or ‘should be avoided’. The following medications should never be used during pregnancy due to the clear risk of teratogenicity or adverse events: bismuth, castor oil, sodium bicarbonate, methotrexate, ribavirin, doxycycline, tetracycline, and thalidomide.
ISSN:1521-6918
1532-1916
DOI:10.1016/j.bpg.2007.06.002