The effects of sulfonylurea glyburide on superoxide dismutase, catalase, and glutathione peroxidase activities in the brain tissue of streptozotocin-induced diabetic rat

Abstract Objectives A member of the second-generation sulfonylureas, glyburide (GLY; glibenclamide) provides an effective therapy for patients with type 2 diabetes. It stimulates pancreatic insulin secretion, suggesting that it is effective in the treatment of type 2 diabetes primarily by elevating...

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Published in:Journal of diabetes and its complications 2009-05, Vol.23 (3), p.209-213
Main Authors: Nazaroglu, Namık K, Sepici-Dincel, Aylin, Altan, Nilgun
Format: Article
Language:English
Subjects:
Animals
Body Weight - drug effects
Brain - drug effects
Brain - enzymology
Brain tissue
Catalase - metabolism
Diabetes mellitus
Diabetes Mellitus, Experimental - chemically induced
Diabetes Mellitus, Experimental - enzymology
Endocrinology & Metabolism
Glutathione Peroxidase - metabolism
Glyburide
Glyburide - pharmacology
Male
Rats
Rats, Sprague-Dawley
Streptozocin - pharmacology
Superoxide dismutase
Superoxide Dismutase - metabolism
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Summary:Abstract Objectives A member of the second-generation sulfonylureas, glyburide (GLY; glibenclamide) provides an effective therapy for patients with type 2 diabetes. It stimulates pancreatic insulin secretion, suggesting that it is effective in the treatment of type 2 diabetes primarily by elevating the circulating insulin levels. However, experimental evidences have indicated that sulfonylureas have also had an extrapancreatic effect, which may directly contribute toward maintaining blood glucose homeostasis during diabetes. Methods In this study, we administrated GLY to streptozotocin-induced diabetic rats and determined the effects of such treatment on activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) from brain tissue. Results and Discussion Brain CAT and GPx activities were not significantly different in the diabetic group compared to controls ( P >.05), but the SOD activity was significantly reduced in the diabetic group compared to controls ( P
ISSN:1056-8727
1873-460X
DOI:10.1016/j.jdiacomp.2007.09.001