Consequences of delayed pump infusion line change in patients with type 1 diabetes mellitus treated with continuous subcutaneous insulin infusion

• Published in: Journal of diabetes and its complications 2010-03, Vol.24 (2), p.73-78
• Main Authors: Thethi, Tina K., MD, Rao, Ajay, MD, Kawji, Haytham, MD, Mallik, Tilak, Yau, C. Lillian, PhD, Christians, Uwe, MD, PhD, Fonseca, Vivian, MD
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Aged; Blood Glucose - analysis; Cross-Over Studies; CSII; Deoxyglucose - blood; Diabetes; Diabetes Mellitus, Type 1 - drug therapy; Double-Blind Method; Endocrinology & Metabolism; F2-Isoprostanes - blood; Fasting - blood; Female; Glucose; Glycemic control; Humans; Hyperglycemia; Hyperglycemia - blood; Infusions, Subcutaneous - adverse effects; Infusions, Subcutaneous - instrumentation; Infusions, Subcutaneous - methods; Insulin; Insulin - administration & dosage; Insulin - analogs & derivatives; Insulin Infusion Systems; Insulin Lispro; Lysine - analogs & derivatives; Lysine - blood; Male; Middle Aged; Pump infusion line; Type 1 Diabetes; Young Adult
• ISSN: 1056-8727; 1873-460X
• DOI: 10.1016/j.jdiacomp.2009.03.002

Abstract Objective To systematically investigate the effect of lack of adherence to the recommended change in insulin pump infusion line use beyond 48 h and determine whether the type of insulin made a difference. Research design and methods This was a double-blind, randomized, crossover trial with 20 patients with diabetes mellitus I using insulins aspart and lispro without a line change for up to 100 h. Using retrospective continuous glucose monitoring, we analyzed the average glucose over the day. Changes in serum 1,5-anhydroglucitol, carboxymethyllysine, and free 15-F2t isoprostane were also studied. Results From Day 2 to Day 5 of the pump line use, the daily average glucose level increased from 122.7 to 163.9 mg/dl ( P