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According to the prevailing view, neoplasias originate as avascular masses that develop the angiogenic ability to progress above a critical size.2 Current evidence indicates that in several different tumor settings, tumor cells initially co-opt existing vessels, which first regress and then in a sub...

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Bibliographic Details
Published in:Human pathology 2003-09, Vol.34 (9), p.959
Main Authors: Tsoli, E, Zacharatos, P, Kotsinas, A, Gorgoulis, V.G
Format: Article
Language:English
Subjects:
Angiogenesis
Breast cancer
Rodents
Signal transduction
Tumors
Vascular endothelial growth factor
Online Access:Get full text
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Summary:According to the prevailing view, neoplasias originate as avascular masses that develop the angiogenic ability to progress above a critical size.2 Current evidence indicates that in several different tumor settings, tumor cells initially co-opt existing vessels, which first regress and then in a subsequent phase remodel, producing new vessels (angiogenesis) to support tumor growth.3 In accordance with this process, 3 distinct angiogenic patterns of tumor growth in non-small cell lung cancer have been described.4 Moreover, the existence of a nonangiogenic/alveolar growth pattern has also been reported.4 Indeed, in our work we regarded whole-tumor microvessel density (MVD) as a measure of angiogenesis for the following reasons.
ISSN:0046-8177
1532-8392
DOI:10.1016/S0046-8177(03)00248-X