Evaluation of the efficacy of vitamin D3 or its metabolites on thiram-induced tibial dyschondroplasia in chickens

Two trials were conducted to determine if thiram-induced tibial dyschondroplasia (TD) in chickens was linked to a vitamin D deficiency and calcium homeostasis dysregulation, and whether feeding vitamin D fortified diets may prevent it. Day-old chickens were given grower diets containing different vi...

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Bibliographic Details
Published in:Research in veterinary science 2007-10, Vol.83 (2), p.244-250
Main Authors: Rath, N.C., Kannan, L., Pillai, P.B., Huff, W.E., Huff, G.R., Horst, R.L., Emmert, J.L.
Format: Article
Language:English
Subjects:
Animal Feed
Animal Nutritional Physiological Phenomena
Animals
Body Weight
Bone and Bones - pathology
Calcitriol - therapeutic use
Chicken
Chickens
Cholecalciferol - metabolism
Cholecalciferol - therapeutic use
Diet
Diet - veterinary
Dietary Supplements
Dose-Response Relationship, Drug
Homeostasis
Ischemia
Metabolites
Minerals - analysis
Osteochondrodysplasias - chemically induced
Osteochondrodysplasias - diet therapy
Osteochondrodysplasias - prevention & control
Osteochondrodysplasias - veterinary
Poultry Diseases - chemically induced
Poultry Diseases - diet therapy
Poultry Diseases - prevention & control
Thiram
Thiram - toxicity
Tibial dyschondroplasia
Veterinary medicine
Vitamin D
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin deficiency
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Summary:Two trials were conducted to determine if thiram-induced tibial dyschondroplasia (TD) in chickens was linked to a vitamin D deficiency and calcium homeostasis dysregulation, and whether feeding vitamin D fortified diets may prevent it. Day-old chickens were given grower diets containing different vitamin D products throughout the experiment until necropsy on day 16. Half of the birds in each feed group received thiram at levels of 100 ppm (trial 1) or 50 ppm (trial 2) between days 7–9 to induce TD. The birds were weighed, bled, and euthanized to determine TD incidences and severity by examining the growth plates. Tibial bones were used to measure biomechanical strength and ash content. Blood concentrations of 25-hydroxyvitamin D, Ca, P, alkaline phosphatase, and creatine kinase were measured in serum that showed no differences between different groups. Thiram reduced body weight and induced TD regardless of any vitamin D treatment to the same extent as untreated birds.
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2006.12.008