curative and antioxidative efficiency of doramectin and doramectin + vitamin AD3E treatment on Psoroptes cuniculi infestation in rabbits

In the present study, the efficiency of the administration of doramectin (DOR) and DOR + vitamin AD3E (VIT), and the influence of these agents on oxidative stress parameters in rabbits infested by Psoroptes cuniculi (P. cuniculi) were investigated. DOR (200 μg/kg) and DOR (200 μg/kg) + VIT AD3E were...

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Bibliographic Details
Published in:Research in veterinary science 2008-10, Vol.85 (2), p.291-293
Main Authors: Kanbur, M, Atalay, O, Ica, A, Eraslan, G, Cam, Y
Format: Article
Language:English
Subjects:
Animals
antioxidant activity
Antioxidants - administration & dosage
Antioxidants - therapeutic use
catalase
cholecalciferol
Drug Combinations
Drug dosages
Drug Therapy, Combination
Efficiency
enzyme activity
erythrocytes
Free radicals
glutathione peroxidase
Insecticides - administration & dosage
Insecticides - therapeutic use
Ivermectin - administration & dosage
Ivermectin - analogs & derivatives
Ivermectin - therapeutic use
malondialdehyde
Mite Infestations - drug therapy
Mite Infestations - veterinary
Oxidative stress
Plasma
Psoroptes cuniculi
psoroptic mange
Psoroptidae - drug effects
rabbit diseases
Rabbits
superoxide dismutase
Veterinary medicine
vitamin A
vitamin E
vitamin supplements
Vitamins - administration & dosage
Vitamins - therapeutic use
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Summary:In the present study, the efficiency of the administration of doramectin (DOR) and DOR + vitamin AD3E (VIT), and the influence of these agents on oxidative stress parameters in rabbits infested by Psoroptes cuniculi (P. cuniculi) were investigated. DOR (200 μg/kg) and DOR (200 μg/kg) + VIT AD3E were administered to infested rabbits intramuscularly (IM). The administration of DOR and DOR + VIT improved the healing of ear lesions on day seven. Increase in the plasma malondialdehyde (MDA) level and erythrocyte catalase (CAT) activity, and decrease in glutathione peroxidase (GSH-Px) and superoxide dismutase (SOD) activities were determined in infested rabbits. In the rabbits which were administered DOR + VIT, plasma MDA levels decreased, and erythrocyte GSH-Px and SOD activities increased on day seven. In conclusion, DOR and DOR + VIT combination were effective against P. cunuculi infestation. Infestation stimulated oxidative stress. VIT treatment resulted in antioxidant activity against oxidative stress induced by P. cuniculi infestation.
ISSN:0034-5288
1532-2661
DOI:10.1016/j.rvsc.2007.10.005