D010: Neurohormonal effects on left ventricular mass in patients with essential hypertension

• Published in: American journal of hypertension 2000-04, Vol.13 (S2), p.161A-161A
• Main Authors: Shigemasa, T., Miyajima, E., Tochikubo, O., Umemura, S.
• Format: Article
• Language: English
• Subjects: Aldosterone; left ventricular hypertrophy; nighttime blood pressure; norepinephrine
• ISSN: 0895-7061; 1941-7225
• DOI: 10.1016/S0895-7061(00)01118-3

To investigate the pathophysiological mechanisms responsible for left ventricular hypertrophy, we examined ambulatory 24-h blood pressure (BP), plasma (PNE) and urinary norepinephrine (UNE), plasma renin activity (PRA), plasma aldosterone concentration (PAC), and left ventricular mass (LVM) in 20 untreated inpatients with essential hypertension (n = 20: 53 ± 3 y; 15 men and 5 women). Each subject ingested a diet of 7 g salt (NaCl) per day for a week. LVM was univariately significantly related to nighttime mean BP and PAC, while daytime mean BP, 24-h mean BP, PRA, PNE and UNE were not significantly related to LVM. By multiple regression analyses, LVM was significantly related to PAC as an independent variable (R2 = 0.58, p < 0.001) but not to nighttime mean BP. Furthermore, both diastolic posterior wall thickness (PWTd) and end-diastolic left ventricular dimension (LVDd) were also significantly related to PAC. However, wall thickness of the interventricular septum (IVSTd) was significantly related to nighttime mean BP but not to PAC. These results indicate that although PWTd, LVDd, IVSTd are significantly related to LVM as independent variables (R2 = 0.981, p < 0.001), both LVDd and PWTd are influenced by PAC and related mechanisms, but IVSTd is influenced by nighttime mean BP.