F016: Nitric oxide activity improvement does not depends on type of hypotensive therapy: 1-year treatment with ENALAPRIL vs INDAPAMIDE SR

• Published in: American journal of hypertension 2000-04, Vol.13 (S2), p.245A-245A
• Main Authors: Soboleva, G.N., Balakhonova, T.V., Rogoza, A.N., Kobilyansky, A., Kuznetcova, T.N., Karpov, Yu.A.
• Format: Article
• Language: English
• Subjects: Endothelial function; hypotensive therapy
• ISSN: 0895-7061; 1941-7225; 1879-1905
• DOI: 10.1016/S0895-7061(00)00943-2

Objective: To investigate the 1-year treatment with Indapamide-slow-release (I-SR) 1.5 mg/day vs Enalapril (E) 20 mg/day effect on endothelium-dependent flow-mediated brachial artery dilatation (FMD) and nitric oxide (NO) activity in Essential hypertension (EH) pts. Design and methods: As a fragment of LIVE study after 2-week placebo-period 25 mild-moderate EH pts were randomised blindly to receive either I-SR (gr1) or E (gr2) for 1 year. Mean disease duration, mean age, sex differences for pts completed the study (Gr1 vs Gr2) were 13,2 ± 1,9 vs 10,3 ± 1,2 (NS) yrs, 51,4 ± 2,3 vs 48,3 ± 2,4 (NS) yrs, 4m/5f vs 7m/5f. FMD was estimated at past placebo-period day (D1) and past treatment day (D365) as diameter changes in postocclusive hyperemia in % of diameter at rest by high resolution ultrasound. Plasma NO, NO2, NO3 activity was determined by HPLC on D1 and D365. Results: shown as M ± SE, *-p < 0,05, **-p < 0,01, ***-p < 0,001 In Gr1 DNO2 correlated with DSBP (r = −,53, p = 0,1), DNO3 with DSBP and DDBP (r = −,44, −,48, p = 0,1). In Gr2 DNO correlated with DDBP, DSBP (r = −,48, −,41, p 5 0,1), DNO3 with DDBP (r = −,48, p = 0,1), DNO2 with DSBP (r = −,56, p = 0,1) and DFMD with DDBP (r = 259, p , 0,05) Conclusion: 1. NO, NO2, NO3 activity increased with BP decrease despite of therapy type, so we can conclude that NO disturbances may be secondary in EH. 2. FMD improvement depends on type of hypotensive therapy. (See Table) SBP (mm Hg) DBP (mmHg) FMD (%) NO2 (μM/l) NO3 (μM/l) NO (μM/l) Gr 1 D1 174,9 ± 2,1 107,6 ± 1,0 7,4 ± 1,0 4,5 ± 0,6 30,0 ± 3,0 34,2 ± 3,2 Gr 1 D365 (n = 10) 156,2 ± 4,9** 98,9 ± 2,0** 4,3 ± 2,0 5,4 ± 0,7 32,7 ± 3,2 38,1 ± 3,2 Gr 2 D1 171,9 ± 1,2 106,7 ± 0,9 9,5 ± 0,6 18,9 ± 9,4 44,8 ± 5,1 63,8 ± 12,4 Gr 2 D365 (n = 12) 155,1 ± 3,3*** 98,6 ± 1,9*** 9,2 ± 0,9 4,9 ± 0,5 51,8 ± 15,8 56,8 ± 1 6,1