H008: Methotrexate fails to suppress cardiac cytokine induction in pressure overload hypertrophy in rats

Elevated plasma levels of IL-6 and IL-1b were found in patients with heart failure and left ventricular hypertrophy (LVH) and correlated with poor outcome. Immunosuppressive agents like Methotrexate (MTx) may lower these cytokines and affect disease progression. Here we studied the effects of MTx in...

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Bibliographic Details
Published in:American journal of hypertension 2000-04, Vol.13 (S2), p.273A-274A
Main Authors: Jeron, A., Fredersdorf, S., Straub, R., Riegger, Günter A.J., Muders, F.
Format: Article
Language:English
Subjects:
cytokines
hypertrophy
Methotrexate
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Summary:Elevated plasma levels of IL-6 and IL-1b were found in patients with heart failure and left ventricular hypertrophy (LVH) and correlated with poor outcome. Immunosuppressive agents like Methotrexate (MTx) may lower these cytokines and affect disease progression. Here we studied the effects of MTx in a rat model of LVH. LVH was induced by aortic banding in 27 rats. Rats were injected with MTx i.p. once a week (M1: 0.3mg/kg; M2: 0.9mg/kg, n=9) or NaCl (AS, n=9) for 8 weeks, starting 4 weeks after aortic banding. Body weight was measured weekly. Cytokines were measured in the superperfusion solution of myocardium slices (6/heart) and in plasma (obtained at week 4, 8 and 12). Body weight and systolic blood pressure were significantly lower in all aortic banding groups compared to 6 sham operated controls (C) (468g–477g vs 532g, p
ISSN:0895-7061
1941-7225
1879-1905
DOI:10.1016/S0895-7061(00)01017-7