Insulin resistance is affected by sodium intake in nonmodulating subset of essential hypertension

Insulin resistance (IR) is one of the possible causes of essential hypertension (EH). Relationship between IR and pathophysiologic mechanisms are poorly understood, although an association between salt sensitive EH and IR has been reported. The purpose of this study was to determine if IR measured u...

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Published in:American journal of hypertension 2000-04, Vol.13 (4), p.8A-8A
Main Authors: Raji, A., Williams, G.H., Xavier, J., Hopkins, P.N., Hunt, S.C., Hollenberg, N.K., Seely, E.W.
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Essential hypertension
Insulin resistance
nonmodulators
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container_issue 4
container_start_page 8A
container_title American journal of hypertension
container_volume 13
creator Raji, A.
Williams, G.H.
Xavier, J.
Hopkins, P.N.
Hunt, S.C.
Hollenberg, N.K.
Seely, E.W.
description Insulin resistance (IR) is one of the possible causes of essential hypertension (EH). Relationship between IR and pathophysiologic mechanisms are poorly understood, although an association between salt sensitive EH and IR has been reported. The purpose of this study was to determine if IR measured using homeostasis model assessment (HOMA) was a) different in subsets of EH determined according to the abnormalities in the renin-angiotensin system: Low renin, Non-modulators (NM), and Modulators. The latter two are normal/high renin group. b) Modified by the level of sodium (Na) intake in the different subsets. Fasting insulin and glucose were determined in subsets of EH and normotensives (NT) and HOMA was calculated as fasting glucose (mmol)* fasting insulin (μmol)/22.5, and was log transformed for analysis. ANOVA, paired t and non-parametric tests were used to compare subsets. EH (N=265) as a whole had significantly higher fasting insulin (p
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Relationship between IR and pathophysiologic mechanisms are poorly understood, although an association between salt sensitive EH and IR has been reported. The purpose of this study was to determine if IR measured using homeostasis model assessment (HOMA) was a) different in subsets of EH determined according to the abnormalities in the renin-angiotensin system: Low renin, Non-modulators (NM), and Modulators. The latter two are normal/high renin group. b) Modified by the level of sodium (Na) intake in the different subsets. Fasting insulin and glucose were determined in subsets of EH and normotensives (NT) and HOMA was calculated as fasting glucose (mmol)* fasting insulin (μmol)/22.5, and was log transformed for analysis. ANOVA, paired t and non-parametric tests were used to compare subsets. EH (N=265) as a whole had significantly higher fasting insulin (p&lt;.001) and HOMA (p&lt;.001) on low Na than NT. Within the EH subsets the NM had the highest fasting insulin levels and HOMA, with further increase in HOMA on low Na (Table). This was independent of the potential confounders of BMI, race and age. Black NM (n = 18) did not show significant change in HOMA (p = .982) or fasting insulin (p = .782) with low Na. HOMA N Low Na High Na Nonmodulators 58 6.12* 4.00 Modulators 129 4.30 3.54 Low Renin 54 2.84 2.24 Normotensives 21 3.84 2.60 *p&lt;0.005 NM are more IR than other subsets of EH. 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source Oxford University Press:Jisc Collections:OUP Read and Publish 2024-2025 (2024 collection) (Reading list)
subjects Essential hypertension
Insulin resistance
nonmodulators
title Insulin resistance is affected by sodium intake in nonmodulating subset of essential hypertension
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