Radiotherapy-induced koebnerization in lichen planus

Biopsy of papules from the right knee and the left foot showed wedge-shaped hypergranulosis, lichenoid infiltrate consisting of lymphocytes hugging the basal layer and saw toothing of the rete ridges [Figure 3]. [...]a diagnosis LP with radiotherapy-induced koebnerization was confirmed. Some of the...

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Bibliographic Details
Published in:Indian journal of dermatology, venereology, and leprology venereology, and leprology, 2012-09, Vol.78 (5), p.665
Main Authors: Sajgane, Avinash A, Dongre, Atul M
Format: Article
Language:English
Subjects:
Adult
Care and treatment
Case studies
Complications and side effects
Diagnosis
Foot
Humans
Knee
Lichen planus
Lichen Planus - etiology
Lichen Planus - pathology
Lymphoma
Lymphoma, Large B-Cell, Diffuse - radiotherapy
Male
Radiation therapy
Radiotherapy
Risk factors
Skin
Skin diseases
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Summary:Biopsy of papules from the right knee and the left foot showed wedge-shaped hypergranulosis, lichenoid infiltrate consisting of lymphocytes hugging the basal layer and saw toothing of the rete ridges [Figure 3]. [...]a diagnosis LP with radiotherapy-induced koebnerization was confirmed. Some of the mechanisms which were put forward includes increased expression of proinflammatory molecules such as major histocompatibility complex (MHC), adhesion molecules (ICAM-1 and E-selectin), increased expression of cytokines (IL-1, IL-6, IL-8,TNF-alpha, TGF beta), release of autoantigens or antigenic peptides by damage caused by radiotherapy, and degradation of the basement membrane by increased matrix metalloproteases (MMPs).
ISSN:0378-6323
0973-3922
1998-3611
DOI:10.4103/0378-6323.100551