Gene balance hypothesis: Connecting issues of dosage sensitivity across biological disciplines

We summarize, in this review, the evidence that genomic balance influences gene expression, quantitative traits, dosage compensation, aneuploid syndromes, population dynamics of copy number variants and differential evolutionary fate of genes after partial or whole-genome duplication. Gene balance e...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2012-09, Vol.109 (37), p.14746-14753
Main Authors: Birchler, James A, Veitia, Reiner A
Format: Article
Language:English
Subjects:
Aneuploidy
Biochemistry, Molecular Biology
Biological Sciences
Chromosomes
Chromosomes - genetics
Drosophila
Evolution
Evolution, Molecular
Evolutionary biology
Evolutionary genetics
Gene dosage
Gene Dosage - physiology
Gene expression
Genes
Genetic variation
Genome - genetics
Genomes
Genomics
Life Sciences
Models, Genetic
Phenotype
Ploidies
population dynamics
Quantitative Trait, Heritable
quantitative traits
signal transduction
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Summary:We summarize, in this review, the evidence that genomic balance influences gene expression, quantitative traits, dosage compensation, aneuploid syndromes, population dynamics of copy number variants and differential evolutionary fate of genes after partial or whole-genome duplication. Gene balance effects are hypothesized to result from stoichiometric differences among members of macromolecular complexes, the interactome, and signaling pathways. The implications of gene balance are discussed.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.1207726109